Version 5.4
Homo sapiens Gene: AXL
Summary
InnateDB Gene IDBG-52651.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol AXL
Gene Name AXL receptor tyrosine kinase
Synonyms JTK11; UFO
Species Homo sapiens
Ensembl Gene ENSG00000167601
Encoded Proteins
IDBP-52653
AXL receptor tyrosine kinase
IDBP-52655
AXL receptor tyrosine kinase
IDBP-765182
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 18083102
AXL is a pleiotropic inhibitor of the innate immune response in dendritic cells, this tyrosine protein kinase is induced by IFNAR/STAT1 signalling and TLR ligation predominantly through TLR activation of the feed-forward cytokine pathway
PMID 19657094
AXL regulates survival and migration of human dendritic cells by an IFN-alpha-inducible AXL/GAS6 pathway.
PMID 23071254
TGF-β1-induced AXL enhances apoptotic cell uptake and blocks proinflammatory cytokine production in the skin.
InnateDB Annotation from Orthologs
Summary
PMID 23954153
[Mus musculus] Viruses engage Tyro3/Axl/Mertk (TAM) receptors in order to inhibit host type I IFN signalling.
Entrez Gene
Summary The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:41219203-41261766
Strand Forward strand
Band q13.2
Transcripts
ENST00000301178 ENSP00000301178
ENST00000359092 ENSP00000351995
ENST00000594880
ENST00000599659
ENST00000593513 ENSP00000471497
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Experimentally validated
Total 41 [view]
Protein-Protein 39 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 6 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001786 phosphatidylserine binding
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016772 transferase activity, transferring phosphorus-containing groups
GO:0032036 myosin heavy chain binding
GO:0043548 phosphatidylinositol 3-kinase binding
GO:0046982 protein heterodimerization activity
Biological Process
GO:0001764 neuron migration
GO:0001779 natural killer cell differentiation
GO:0001961 positive regulation of cytokine-mediated signaling pathway
GO:0001974 blood vessel remodeling
GO:0006468 protein phosphorylation
GO:0006909 phagocytosis
GO:0006954 inflammatory response
GO:0007165 signal transduction
GO:0007167 enzyme linked receptor protein signaling pathway
GO:0007283 spermatogenesis
GO:0018108 peptidyl-tyrosine phosphorylation
GO:0021885 forebrain cell migration
GO:0030154 cell differentiation
GO:0030168 platelet activation
GO:0031100 organ regeneration
GO:0031668 cellular response to extracellular stimulus
GO:0032689 negative regulation of interferon-gamma production
GO:0032720 negative regulation of tumor necrosis factor production
GO:0032825 positive regulation of natural killer cell differentiation
GO:0032940 secretion by cell
GO:0034101 erythrocyte homeostasis
GO:0034446 substrate adhesion-dependent cell spreading
GO:0035457 cellular response to interferon-alpha
GO:0042698 ovulation cycle
GO:0043066 negative regulation of apoptotic process
GO:0043277 apoptotic cell clearance
GO:0043491 protein kinase B signaling
GO:0043524 negative regulation of neuron apoptotic process
GO:0045087 innate immune response (InnateDB)
GO:0048469 cell maturation
GO:0051250 negative regulation of lymphocyte activation
GO:0051897 positive regulation of protein kinase B signaling
GO:0060068 vagina development
GO:0070301 cellular response to hydrogen peroxide
GO:0071222 cellular response to lipopolysaccharide
GO:0097028 dendritic cell differentiation
GO:2000669 negative regulation of dendritic cell apoptotic process
Cellular Component
GO:0005615 extracellular space
GO:0005887 integral component of plasma membrane
GO:0009986 cell surface
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000002602
View Gene Order
ENSBTAG00000003166
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
REACTOME
REACT_12529
Signaling by VEGF pathway
REACT_111102
Signal Transduction pathway
REACT_228166
VEGFA-VEGFR2 Pathway pathway
KEGG
INOH
PID NCI
deltanp63pathway
Validated transcriptional targets of deltaNp63 isoforms
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.590970 Hs.703346
RefSeq NM_001278599 NM_001699 NM_021913
HUGO
OMIM
CCDS CCDS12574 CCDS12575 CCDS62677
HPRD 00171
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca