|Homo sapiens Gene: AXL|
|Last Modified||2014-10-13 [Report errors or provide feedback]|
|Gene Name||AXL receptor tyrosine kinase|
AXL receptor tyrosine kinase
AXL receptor tyrosine kinase
|Useful resources||Stemformatics EHFPI ImmGen|
AXL is a pleiotropic inhibitor of the innate immune response in dendritic cells, this tyrosine protein kinase is induced by IFNAR/STAT1 signalling and TLR ligation predominantly through TLR activation of the feed-forward cytokine pathway
AXL regulates survival and migration of human dendritic cells by an IFN-alpha-inducible AXL/GAS6 pathway.
TGF-β1-induced AXL enhances apoptotic cell uptake and blocks proinflammatory cytokine production in the skin.
|InnateDB Annotation from Orthologs|
[Mus musculus] Viruses engage Tyro3/Axl/Mertk (TAM) receptors in order to inhibit host type I IFN signalling.
The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other receptor tyrosine kinases, this protein represents a unique structure of the extracellular region that juxtaposes IgL and FNIII repeats. It transduces signals from the extracellular matrix into the cytoplasm by binding growth factors like vitamin K-dependent protein growth-arrest-specific gene 6. It is involved in the stimulation of cell proliferation and can also mediate cell aggregation by homophilic binding. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
The protein encoded by this gene is a member of the Tyro3-Axl-Mer (TAM) receptor tyrosine kinase subfamily. The encoded protein possesses an extracellular domain which is composed of two immunoglobulin-like motifs at the N-terminal, followed by two fibronectin type-III motifs. It transduces signals from the extracellular matrix into the cytoplasm by binding to the vitamin K-dependent protein growth arrest-specific 6 (Gas6). This gene may be involved in several cellular functions including growth, migration, aggregation and anti-inflammation in multiple cell types. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
|Genomic Location||Chromosome 19:41219203-41261766|
|Number of Interactions||
This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 6 interaction(s) predicted by orthology.
Possible paralog/unusual divergence/ gene prediction error
Signaling by VEGF pathway
Signal Transduction pathway
VEGFA-VEGFR2 Pathway pathway
Validated transcriptional targets of deltaNp63 isoforms
|UniProt Splice Variant|
|RefSeq||NM_021913 NM_001699 NM_001278599|
|CCDS||CCDS12575 CCDS12574 CCDS62677|
|EMBL||AC011510 BC032229 M76125 S65125 X57019 X66030|
|GenPept||AAA61243 AAB20305 AAH32229 CAA40338 CAA46829|
|RNA Seq Atlas||558|