Version 5.4
Homo sapiens Gene: PARP14
Summary
InnateDB Gene IDBG-52688.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PARP14
Gene Name poly (ADP-ribose) polymerase family, member 14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173193
Encoded Proteins
IDBP-477436
poly (ADP-ribose) polymerase family, member 14
IDBP-484801
poly (ADP-ribose) polymerase family, member 14
IDBP-479151
poly (ADP-ribose) polymerase family, member 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Poly(ADP-ribosyl)ation is an immediate DNA damage-dependent posttranslational modification of histones and other nuclear proteins that contributes to the survival of injured proliferating cells. PARP14 belongs to the superfamily of enzymes that perform this modification (Ame et al., 2004 [PubMed 15273990]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:122680618-122730840
Strand Forward strand
Band q21.1
Transcripts
ENST00000474629 ENSP00000418194
ENST00000494811 ENSP00000418535
ENST00000483611
ENST00000460683 ENSP00000420649
ENST00000474669
ENST00000475640
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 13 [view]
Protein-Protein 12 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003950 NAD+ ADP-ribosyltransferase activity
GO:0005515 protein binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034422
View Gene Order
ENSBTAG00000016656
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
il4_2pathway
IL4-mediated signaling events
Cross-References
SwissProt Q460N5
TrEMBL H7C5R8
UniProt Splice Variant
Entrez Gene 54625
UniGene Hs.518203 Hs.619286
RefSeq NM_017554 XM_005247545
HUGO HGNC:29232
OMIM 610028
CCDS CCDS46894
HPRD
IMGT
EMBL AB033094 AC048348 AC092908 AK001770 AK022542 AK304269 AY134858 DB237115 DQ063584 DQ063585
GenPept AAN08627 AAY64449 AAY64450 BAA86582 BAA91897 BAB14089 BAG65132
RNA Seq Atlas 54625

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca