Version 5.4
Homo sapiens Gene: ACER2
Summary
InnateDB Gene IDBG-52948.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACER2
Gene Name alkaline ceramidase 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000177076
Encoded Proteins
IDBP-52950
alkaline ceramidase 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 9:19409059-19452020
Strand Forward strand
Band p22.1
Transcripts
ENST00000340967 ENSP00000342609
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 0
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0016811 hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides
GO:0017040 ceramidase activity
GO:0071633 dihydroceramidase activity
Biological Process
GO:0001953 negative regulation of cell-matrix adhesion
GO:0006665 sphingolipid metabolic process
GO:0006672 ceramide metabolic process
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0008284 positive regulation of cell proliferation
GO:0010942 positive regulation of cell death
GO:0030148 sphingolipid biosynthetic process
GO:0032526 response to retinoic acid
GO:0033629 negative regulation of cell adhesion mediated by integrin
GO:0035690 cellular response to drug
GO:0044281 small molecule metabolic process
GO:0046512 sphingosine biosynthetic process
GO:0090285 negative regulation of protein glycosylation in Golgi
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0016021 integral component of membrane
GO:0030173 integral component of Golgi membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038007
View Gene Order
ENSBTAG00000010821
Not yet available
Pathways
NETPATH
REACTOME
REACT_115810
Sphingolipid de novo biosynthesis pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00600
Sphingolipid metabolism pathway
INOH
PID NCI
Cross-References
SwissProt Q5QJU3
TrEMBL
UniProt Splice Variant
Entrez Gene 340485
UniGene Hs.41379
RefSeq NM_001010887 XM_005251448
HUGO HGNC:23675
OMIM 613492
CCDS CCDS34992
HPRD
IMGT
EMBL AF370405 AL158206 AL391834 AY312516 BC092487
GenPept AAH92487 AAQ15241 AAQ85132 CAH73022 CAM21146
RNA Seq Atlas 340485

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca