InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: CSNK1A1

Summary

InnateDB Gene

IDBG-52965.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

CSNK1A1

Gene Name

casein kinase 1, alpha 1

Synonyms

CK1; CK1a; CKIa; HEL-S-77p; HLCDGP1; PRO2975

Species

Homo sapiens

Ensembl Gene

ENSG00000113712

Encoded Proteins

IDBP-52967

casein kinase 1, alpha 1

IDBP-52969

casein kinase 1, alpha 1

IDBP-479363

casein kinase 1, alpha 1

IDBP-480469

casein kinase 1, alpha 1

IDBP-474916

casein kinase 1, alpha 1

IDBP-483266

casein kinase 1, alpha 1

IDBP-474655

casein kinase 1, alpha 1

IDBP-473910

casein kinase 1, alpha 1

IDBP-808933

casein kinase 1, alpha 1

IDBP-808937

casein kinase 1, alpha 1

IDBP-808938

casein kinase 1, alpha 1

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:149492197-149551552

Strand

Reverse strand

Band

q32

Transcripts

ENST00000261798	ENSP00000261798
ENST00000377843	ENSP00000367074
ENST00000504676	ENSP00000426747
ENST00000515435	ENSP00000427031
ENST00000515768	ENSP00000421689
ENST00000503350	ENSP00000425366
ENST00000523203	ENSP00000430252
ENST00000515748	ENSP00000421268
ENST00000606719	ENSP00000475319
ENST00000606826	ENSP00000475969
ENST00000606299	ENSP00000475633

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 102 experimentally validated interaction(s) in this database.

Experimentally validated
Total	102 [view]
Protein-Protein	101 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0007067	mitotic nuclear division
GO:0007165	signal transduction
GO:0007166	cell surface receptor signaling pathway
GO:0008152	metabolic process
GO:0016055	Wnt signaling pathway

Cellular Component

GO:0000777	condensed chromosome kinetochore
GO:0005813	centrosome
GO:0005829	cytosol
GO:0005847	mRNA cleavage and polyadenylation specificity factor complex
GO:0016020	membrane
GO:0016607	nuclear speck

Orthologs

No orthologs found for this gene

Pathways

NETPATH

NetPath_8

Wnt pathway

REACTOME

REACT_11065

Beta-catenin phosphorylation cascade pathway

REACT_11063

Degradation of beta-catenin by the destruction complex pathway

REACT_228216

truncated APC mutants destabilize the destruction complex pathway

REACT_228098

AXIN mutants destabilize the destruction complex, activating WNT signaling pathway

REACT_228143

APC truncation mutants are not K63 polyubiquitinated pathway

REACT_228134

Signaling by Hedgehog pathway

REACT_228243

AMER1 mutants destabilize the destruction complex pathway

REACT_228096

misspliced LRP5 mutants have enhanced beta-catenin-dependent signaling pathway

REACT_228331

Signaling by WNT in cancer pathway

REACT_228285

AXIN missense mutants destabilize the destruction complex pathway

REACT_11045

Signaling by Wnt pathway

REACT_200610

disassembly of the destruction complex and recruitment of AXIN to the membrane pathway

REACT_228196

APC truncation mutants have impaired AXIN binding pathway

REACT_206597

Degradation of GLI2 by the proteasome pathway

REACT_231645

GLI3 is processed to GLI3R by the proteasome pathway

REACT_228261

T41 mutants of beta-catenin aren't phosphorylated pathway

REACT_111102

Signal Transduction pathway

REACT_267634

Hedgehog 'off' state pathway

REACT_228314

misspliced GSK3beta mutants stabilize beta-catenin pathway

REACT_228137

S45 mutants of beta-catenin aren't phosphorylated pathway

REACT_228048

deletions in the AMER1 gene destabilize the destruction complex pathway

REACT_228159

S33 mutants of beta-catenin aren't phosphorylated pathway

REACT_228060

truncations of AMER1 destabilize the destruction complex pathway

REACT_228229

phosphorylation site mutants of CTNNB1 are not targeted to the proteasome by the destruction complex pathway

REACT_200777

TCF dependent signaling in response to WNT pathway

REACT_228112

deletions in the AXIN genes in hepatocellular carcinoma result in elevated WNT signaling pathway

REACT_228188

RNF mutants show enhanced WNT signaling and proliferation pathway

REACT_228223

TCF7L2 mutants don't bind CTBP pathway

REACT_228279

XAV939 inhibits tankyrase, stabilizing AXIN pathway

REACT_228251

S37 mutants of beta-catenin aren't phosphorylated pathway

REACT_116125

Disease pathway

KEGG

hsa04310

Wnt signaling pathway pathway

hsa04340

Hedgehog signaling pathway pathway

INOH

INOH website

IL-7 signaling pathway

INOH website

JAK STAT pathway and regulation pathway

INOH website

EPO signaling pathway pathway

INOH website

VEGF signaling pathway pathway

PID NCI

ps1pathway

Presenilin action in Notch and Wnt signaling

nfat_3pathway

Role of Calcineurin-dependent NFAT signaling in lymphocytes

wnt_noncanonical_pathway

Noncanonical Wnt signaling pathway

Cross-References

SwissProt

P48729

TrEMBL

B4DER9 U3KPX3 U3KQ83

UniProt Splice Variant

Entrez Gene

1452

UniGene

Hs.629008 Hs.638791 Hs.644579 Hs.712879

RefSeq

NM_001025105 NM_001271741 NM_001271742 NM_001892

HUGO

HGNC:2451

OMIM

600505

CCDS

CCDS47304 CCDS47303 CCDS64291

HPRD

02739

IMGT

EMBL

AC021078 AF218004 AK293761 AK294942 BC008717 BT019829 BT019830 CH471062 CR542206 DQ082865 L37042 X80693

GenPept

AAC41760 AAG17246 AAH08717 AAV38632 AAV38633 AAY84562 BAG57180 BAG58018 CAA56710 CAG47002 EAW61767 EAW61769 EAW61773 EAW61774 EAW61776

RNA Seq Atlas

1452