InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MPP3

Summary

InnateDB Gene

IDBG-52989.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MPP3

Gene Name

membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

Synonyms

DLG3

Species

Homo sapiens

Ensembl Gene

ENSG00000161647

Encoded Proteins

IDBP-233143

membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

IDBP-233145

membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3)

IDBP-764650

IDBP-764909

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally supported, but it doesn't encode a protein. [provided by RefSeq, Jul 2008]
This gene product is a member of a family of membrane-associated proteins termed MAGUKs (membrane-associated guanylate kinase homologs). MAGUKs interact with the cytoskeleton and regulate cell proliferation, signaling pathways, and intracellular junctions. This protein contains a conserved sequence, called the SH3 (src homology 3) motif, found in several other proteins that associate with the cytoskeleton and are suspected to play important roles in signal transduction. Alternatively spliced transcript variants have been identified. One transcript variant is experimentally supported, but it doesn\'t encode a protein. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:43800799-43833170

Strand

Reverse strand

Band

q21.31

Transcripts

ENST00000398393	ENSP00000381430
ENST00000398389	ENSP00000381425
ENST00000496503	ENSP00000465486
ENST00000486600
ENST00000466083
ENST00000479797	ENSP00000467453
ENST00000475450
ENST00000480958
ENST00000589375

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 23 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	23 [view]
Protein-Protein	23 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004385	guanylate kinase activity
GO:0005515	protein binding
GO:0030165	PDZ domain binding

Biological Process

GO:0007165	signal transduction
GO:0046939	nucleotide phosphorylation

Cellular Component

GO:0005887

integral component of plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000052373

View Gene Order

ENSBTAG00000017536

Not yet available

Cross-References

SwissProt

Q13368

TrEMBL

UniProt Splice Variant

Entrez Gene

4356

UniGene

Hs.396566

RefSeq

NM_001932 XM_006721915 XM_006721917

HUGO

HGNC:7221

OMIM

601114

CCDS

CCDS42344

HPRD

03069

IMGT

EMBL

AK313045 AM050144 AM050145 BC047017 BC056865 CH471178 U37707

GenPept

AAB36964 AAH47017 AAH56865 BAG35877 CAJ18313 CAJ18315 EAW51664 EAW51665

RNA Seq Atlas

4356