InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SLC24A2

Summary

InnateDB Gene

IDBG-52997.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SLC24A2

Gene Name

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

Synonyms

NCKX2

Species

Homo sapiens

Ensembl Gene

ENSG00000155886

Encoded Proteins

IDBP-52999

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

IDBP-53001

solute carrier family 24 (sodium/potassium/calcium exchanger), member 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the calcium/cation antiporter superfamily of transport proteins. The encoded protein belongs to the SLC24 branch of exchangers, which can mediate the extrusion of one Ca2+ ion and one K+ ion in exchange for four Na+ ions. This family member is a retinal cone/brain exchanger that can mediate a light-induced decrease in free Ca2+ concentration. This protein may also play a neuroprotective role during ischemic brain injury. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 9:19507452-19786928

Strand

Reverse strand

Band

p22.1

Transcripts

ENST00000341998	ENSP00000344801
ENST00000286344	ENSP00000286344

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005262	calcium channel activity
GO:0005509	calcium ion binding
GO:0008273	calcium, potassium:sodium antiporter activity
GO:0015293	symporter activity
GO:0016151	nickel cation binding
GO:0030145	manganese ion binding
GO:0030955	potassium ion binding
GO:0031402	sodium ion binding
GO:0046870	cadmium ion binding
GO:0046983	protein dimerization activity

Biological Process

GO:0006811	ion transport
GO:0006813	potassium ion transport
GO:0006816	calcium ion transport
GO:0006874	cellular calcium ion homeostasis
GO:0007601	visual perception
GO:0007612	learning
GO:0007613	memory
GO:0034220	ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0055085	transmembrane transport
GO:0060291	long-term synaptic potentiation
GO:0060292	long term synaptic depression
GO:0070588	calcium ion transmembrane transport

Cellular Component

GO:0005886	plasma membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0031226	intrinsic component of plasma membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000037996

View Gene Order

ENSBTAG00000043972

Not yet available

Pathways

NETPATH

REACTOME

REACT_19320

Sodium/Calcium exchangers pathway

REACT_19397

Transport of inorganic cations/anions and amino acids/oligopeptides pathway

REACT_15518

Transmembrane transport of small molecules pathway

REACT_19118

SLC-mediated transmembrane transport pathway

KEGG

INOH

PID NCI

cone_pathway

Visual signal transduction: Cones

Cross-References

SwissProt

Q9UI40

TrEMBL

UniProt Splice Variant

Entrez Gene

25769

UniGene

Hs.283014

RefSeq

NM_001193288 NM_020344 XM_005251425 XM_005251426 XM_006716750

HUGO

HGNC:10976

OMIM

609838

CCDS

CCDS55297 CCDS6493

HPRD

IMGT

EMBL

AF097366 AF177987 AL133281 AL158077 AL158206 BC069622 BC143889

GenPept

AAF21810 AAF25811 AAH69622 AAI43890 CAH71736 CAH71737 CAH73020 CAH73021 CAH74108 CAH74109

RNA Seq Atlas

25769