InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HDAC5

Summary

InnateDB Gene

IDBG-53295.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HDAC5

Gene Name

histone deacetylase 5

Synonyms

HD5; NY-CO-9

Species

Homo sapiens

Ensembl Gene

ENSG00000108840

Encoded Proteins

IDBP-53297

histone deacetylase 5

IDBP-53299

histone deacetylase 5

IDBP-760073

IDBP-758313

IDBP-761630

IDBP-758482

IDBP-762730

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:44076746-44123702

Strand

Reverse strand

Band

q21.31

Transcripts

ENST00000225983	ENSP00000225983
ENST00000336057	ENSP00000337290
ENST00000586802	ENSP00000468004
ENST00000593013
ENST00000586339
ENST00000587135	ENSP00000465393
ENST00000588261	ENSP00000465227
ENST00000588419
ENST00000592385
ENST00000588703	ENSP00000465229
ENST00000587776
ENST00000591714	ENSP00000468485

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 368 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	368 [view]
Protein-Protein	365 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003714	transcription corepressor activity
GO:0004407	histone deacetylase activity
GO:0005080	protein kinase C binding
GO:0005515	protein binding
GO:0008134	transcription factor binding
GO:0032041	NAD-dependent histone deacetylase activity (H3-K14 specific)
GO:0044212	transcription regulatory region DNA binding
GO:0046872	metal ion binding
GO:0046969	NAD-dependent histone deacetylase activity (H3-K9 specific)
GO:0046970	NAD-dependent histone deacetylase activity (H4-K16 specific)
GO:0070491	repressing transcription factor binding
GO:0097372	NAD-dependent histone deacetylase activity (H3-K18 specific)

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0002076	osteoblast development
GO:0006325	chromatin organization
GO:0006338	chromatin remodeling
GO:0006342	chromatin silencing
GO:0006351	transcription, DNA-templated
GO:0006954	inflammatory response
GO:0007219	Notch signaling pathway
GO:0007507	heart development
GO:0010830	regulation of myotube differentiation
GO:0010832	negative regulation of myotube differentiation
GO:0016568	chromatin modification
GO:0016575	histone deacetylation
GO:0030183	B cell differentiation
GO:0032869	cellular response to insulin stimulus
GO:0033555	multicellular organismal response to stress
GO:0042113	B cell activation
GO:0042220	response to cocaine
GO:0042493	response to drug
GO:0043393	regulation of protein binding
GO:0045668	negative regulation of osteoblast differentiation
GO:0045892	negative regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048742	regulation of skeletal muscle fiber development
GO:0051091	positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051153	regulation of striated muscle cell differentiation
GO:0070932	histone H3 deacetylation
GO:0070933	histone H4 deacetylation
GO:0090051	negative regulation of cell migration involved in sprouting angiogenesis

Cellular Component

GO:0000118	histone deacetylase complex
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016604	nuclear body
GO:0043234	protein complex