InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS19

Summary

InnateDB Gene

IDBG-53332.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS19

Gene Name

ribosomal protein S19

Synonyms

DBA; DBA1; S19

Species

Homo sapiens

Ensembl Gene

ENSG00000105372

Encoded Proteins

IDBP-53334

ribosomal protein S19

IDBP-762151

IDBP-762187

IDBP-763380

IDBP-765388

IDBP-762779

IDBP-763591

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 19155217

RPS19 interacts with macrophage migration inhibitory factor (MIF) and attenuates its pro-inflammatory function by inhibiting the MIF-CD74 interaction and MIF triggered adhesion of monocytes.

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S19E family of ribosomal proteins. It is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia (DBA), a constitutional erythroblastopenia characterized by absent or decreased erythroid precursors, in a subset of patients. This suggests a possible extra-ribosomal function for this gene in erythropoietic differentiation and proliferation, in addition to its ribosomal function. Higher expression levels of this gene in some primary colon carcinomas compared to matched normal colon tissues has been observed. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:41859918-41872926

Strand

Forward strand

Band

q13.2

Transcripts

ENST00000221975	ENSP00000221975
ENST00000598261	ENSP00000469798
ENST00000598466
ENST00000600467	ENSP00000469228
ENST00000598742	ENSP00000470972
ENST00000593863	ENSP00000470004
ENST00000598399	ENSP00000472660
ENST00000601492	ENSP00000471621

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 147 experimentally validated interaction(s) in this database.

Experimentally validated
Total	147 [view]
Protein-Protein	144 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0005515	protein binding
GO:0017134	fibroblast growth factor binding
GO:0019901	protein kinase binding
GO:0042803	protein homodimerization activity
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000028	ribosomal small subunit assembly
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0000462	maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0002548	monocyte chemotaxis
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0007000	nucleolus organization
GO:0009991	response to extracellular stimulus
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0030218	erythrocyte differentiation
GO:0030490	maturation of SSU-rRNA
GO:0042274	ribosomal small subunit biogenesis
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)
GO:0051262	protein tetramerization
GO:0051272	positive regulation of cellular component movement
GO:0060265	positive regulation of respiratory burst involved in inflammatory response
GO:0060266	negative regulation of respiratory burst involved in inflammatory response

Cellular Component

GO:0005622	intracellular
GO:0005730	nucleolus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022627	cytosolic small ribosomal subunit
GO:0070062	extracellular vesicular exosome