Version 5.4
Homo sapiens Gene: COMMD1
Summary
InnateDB Gene IDBG-53457.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol COMMD1
Gene Name copper metabolism (Murr1) domain containing 1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000173163
Encoded Proteins
IDBP-53459
copper metabolism (Murr1) domain containing 1
IDBP-377476
copper metabolism (Murr1) domain containing 1
IDBP-377479
copper metabolism (Murr1) domain containing 1
IDBP-377481
copper metabolism (Murr1) domain containing 1
IDBP-377483
copper metabolism (Murr1) domain containing 1
IDBP-377484
copper metabolism (Murr1) domain containing 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary COMMD1 is a regulator of copper homeostasis, sodium uptake, and NF-kappa-B (see MIM 164011) signaling (de Bie et al., 2005 [PubMed 16267171]).[supplied by OMIM, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:61888724-62147247
Strand Forward strand
Band p15
Transcripts
ENST00000311832 ENSP00000308236
ENST00000445644 ENSP00000416997
ENST00000455659 ENSP00000398727
ENST00000427417 ENSP00000413207
ENST00000458337 ENSP00000401236
ENST00000444166 ENSP00000410050
ENST00000472729
ENST00000471704
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 73 experimentally validated interaction(s) in this database.
Experimentally validated
Total 73 [view]
Protein-Protein 73 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0031398 positive regulation of protein ubiquitination
GO:0032088 negative regulation of NF-kappaB transcription factor activity
GO:0032434 regulation of proteasomal ubiquitin-dependent protein catabolic process
GO:0055070 copper ion homeostasis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0031462 Cul2-RING ubiquitin ligase complex
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000051355
View Gene Order
ENSBTAG00000019867
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_152516 XM_005264157
HUGO
OMIM
CCDS CCDS1869
HPRD 06253
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca