Version 5.4
Homo sapiens Gene: TFDP1
Summary
InnateDB Gene IDBG-53460.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TFDP1
Gene Name transcription factor Dp-1
Synonyms Dp-1; DP1; DRTF1
Species Homo sapiens
Ensembl Gene ENSG00000198176
Encoded Proteins
IDBP-53462
transcription factor Dp-1
IDBP-294326
transcription factor Dp-1
IDBP-374366
transcription factor Dp-1
IDBP-592591
transcription factor Dp-1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of a family of transcription factors that heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. The encoded protein functions as part of this complex to control the transcriptional activity of numerous genes involved in cell cycle progression from G1 to S phase. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 1, 15, and X.[provided by RefSeq, Jan 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 13:113584721-113641470
Strand Forward strand
Band q34
Transcripts
ENST00000375370 ENSP00000364519
ENST00000408980 ENSP00000386145
ENST00000453989 ENSP00000401389
ENST00000475254
ENST00000464794
ENST00000465174
ENST00000494812
ENST00000544902 ENSP00000438450
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 55 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 58 [view]
Protein-Protein 53 [view]
Protein-DNA 4 [view]
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
Biological Process
GO:0000082 G1/S transition of mitotic cell cycle
GO:0000278 mitotic cell cycle
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006367 transcription initiation from RNA polymerase II promoter
GO:0006915 apoptotic process
GO:0007049 cell cycle
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007219 Notch signaling pathway
GO:0008283 cell proliferation
GO:0008544 epidermis development
GO:0010467 gene expression
GO:0043276 anoikis
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0097193 intrinsic apoptotic signaling pathway
GO:1900740 positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway
GO:2000278 regulation of DNA biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005667 transcription factor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038482
View Gene Order
ENSBTAG00000019645
Not yet available
Pathways
NETPATH
NetPath_7
TGF_beta_Receptor pathway
REACTOME
REACT_111214
G0 and Early G1 pathway
REACT_683
G1/S-Specific Transcription pathway
REACT_329
Inhibition of replication initiation of damaged DNA by RB1/E2F1 pathway
REACT_471
E2F mediated regulation of DNA replication pathway
REACT_821
Cyclin D associated events in G1 pathway
REACT_120734
SMAD2/SMAD3:SMAD4 heterotrimer regulates transcription pathway
REACT_118568
Pre-NOTCH Transcription and Translation pathway
REACT_1194
Activation of NOXA and translocation to mitochondria pathway
REACT_121
Activation of PUMA and translocation to mitochondria pathway
REACT_12627
Generic Transcription Pathway pathway
REACT_1590
G1 Phase pathway
REACT_120956
Cellular responses to stress pathway
REACT_169107
SMAD4 MH2 Domain Mutants in Cancer pathway
REACT_169325
Oncogene Induced Senescence pathway
REACT_169219
Loss of Function of SMAD4 in Cancer pathway
REACT_169398
Loss of Function of SMAD2/3 in Cancer pathway
REACT_118744
Pre-NOTCH Expression and Processing pathway
REACT_169122
Signaling by TGF-beta Receptor Complex in Cancer pathway
REACT_21267
Mitotic G1-G1/S phases pathway
REACT_169192
TGFBR2 MSI Frameshift Mutants in Cancer pathway
REACT_1783
G1/S Transition pathway
REACT_578
Apoptosis pathway
REACT_111102
Signal Transduction pathway
REACT_121061
Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer pathway
REACT_169165
SMAD2/3 MH2 Domain Mutants in Cancer pathway
REACT_169435
Loss of Function of TGFBR2 in Cancer pathway
REACT_115566
Cell Cycle pathway
REACT_697
Activation of BH3-only proteins pathway
REACT_169103
SMAD2/3 Phosphorylation Motif Mutants in Cancer pathway
REACT_169274
Cellular Senescence pathway
REACT_299
Signaling by NOTCH pathway
REACT_169263
TGFBR1 KD Mutants in Cancer pathway
REACT_152
Cell Cycle, Mitotic pathway
REACT_169311
Loss of Function of TGFBR1 in Cancer pathway
REACT_169445
TGFBR1 LBD Mutants in Cancer pathway
REACT_964
Intrinsic Pathway for Apoptosis pathway
REACT_169440
TGFBR2 Kinase Domain Mutants in Cancer pathway
REACT_169436
Oxidative Stress Induced Senescence pathway
REACT_71
Gene Expression pathway
REACT_116125
Disease pathway
REACT_6844
Signaling by TGF-beta Receptor Complex pathway
KEGG
hsa04350
TGF-beta signaling pathway pathway
hsa04110
Cell cycle pathway
INOH
PID NCI
rb_1pathway
Regulation of retinoblastoma protein
p53downstreampathway
Direct p53 effectors
e2f_pathway
E2F transcription factor network
smad2_3nuclearpathway
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.79353
RefSeq NM_007111 XM_005268326 XM_005268327 XM_005268328
HUGO
OMIM
CCDS CCDS9538
HPRD 01792
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca