Homo sapiens Gene: IFNB1
Summary
InnateDB Gene IDBG-53485.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IFNB1
Gene Name interferon, beta 1, fibroblast
Synonyms IFB; IFF; IFNB;
Species Homo sapiens
Ensembl Gene ENSG00000171855
Encoded Proteins
interferon, beta 1, fibroblast
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
IFNB1 has an essential role in the anti-viral response and optineurin (OPTN) has a role in the inhibition of virus-triggered IFNB1 induction.
Viral RNA-induced IFNB1 production is suppressed by oncogenic RAS through negative regulation of RIG-I signalling, leading to promotion of virus spread.
IFNB1 expression is inhibited by influenza A virus polymerase by binding to IFN-beta promoter stimulator 1 (MAVS).
IFNB1 is a type I interferon (IFN-I) and the IFN-I family comprises a wide number of cytokines with different modulatory effects on angiogenesis, cell growth, fibrosis, apoptosis and autoimmunity.
IFNB1 deficiency results in a partial suppression of the sterol pathway in macrophages during viral infections, thereby linking the regulation of lipid metabolism pathway with interferon anti-viral defence responses. (Demonstrated in murine model)
IFNB1 secretion is greater upon viable E. coli infection in comparison to heat killed E. coli vaccine or LPS. The induction of IFNB1 is dependent on TICAM1-IRF3 signalling. (Demonstrated in murine model).
IFNB1 expression pattern during viral infection is a highly stochastic process influenced by cell-to-cell variability in viral induction processes. (Demonstrated in mice)
IFNB1 production is fundamental to the efficient control of Listeria monocytogenes during the early innate phase of infection. NK cells treated with IFNB1 during early infection were able to reduce bacterial titer in the spleen and significantly improve survival of infected mice. (Demonstrated in mouse)
Macrocyclic NS3-4A resistance-associated amino acid variants (RAVs) with substitutions at residue D168 of the hepatitis C virus protease result in an increased capacity of NS3-4A to cleave MAVS and suppress IFNB1 induction.
Coronavirus engages papain-like proteases to escape from the innate antiviral response of the host by inhibiting TP53-IRF7-IFNB1 signalling.
Hepatitis B virus (HBV) polymerase inhibits TMEM173-stimulated IRF3 activation and IFNB1 induction.
ELAVL1 is required for the stabilization of IFNB1 mRNA, and suppression of ELAVL1 leads to impaired expression of IFNB1 in response to poly(I:C) treatment.
IFNB1 selectively restricts the transcriptional responses mediated by both the TLRs and the NOD-like receptors in Salmonella enterica serovar Typhimurium infection in macrophages.
InnateDB Annotation from Orthologs
Summary
[Mus musculus] Ifnb1 deficiency results in a partial suppression of the sterol pathway in macrophages during viral infections, thereby linking the regulation of lipid metabolism pathway with interferon anti-viral defence responses.
[Mus musculus] Ifnb1 secretion is greater upon viable E. coli infection in comparison to heat killed E. coli vaccine or LPS. The induction of Ifnb1 is dependent on Ticam1-Irf3 signalling.
[Mus musculus] Ifnb1 expression pattern during viral infection is a highly stochastic process influenced by cell-to-cell variability in viral induction processes.
[Mus musculus] Ifnb1 production is fundamental to the efficient control of Listeria monocytogenes during the early innate phase of infection. NK cells treated with Ifnb1 during early infection were able to reduce bacterial titer in the spleen and significantly improve survival of infected mice.
[Mus musculus] The noncanonical NFκB pathway regulates histone modifications at the Ifnb1 promoter resulting in attenuated recruitment of Rela and histone demethylase, Kdm4a, to the Ifnb1 promoter. This provides a mechanism for regulating the induction of type I interferons .
[Mus musculus] The innate immune system plays a role in immunogenic tumour recognition. Tumor-cell-derived DNA triggers Ifnb1 production and dendritic cell activation via Tmem173 and Irf3 cytosolic DNA sensing pathways.
[Mus musculus] Ifnb1 selectively restricts the transcriptional responses mediated by both the TLRs and the NOD-like receptors in Salmonella enterica serovar Typhimurium infection in macrophages.
[Mus musculus] Atf3 plays an important role in modulating IFN responses in macrophages by controlling basal and inducible levels of Ifnb1, as well as the expression of genes downstream of IFN signalling.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 9:21077105-21077963
Strand Reverse strand
Band p21.3
Transcripts
ENST00000380232 ENSP00000369581
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 45 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 6 [view]
Protein-DNA 39 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005126 cytokine receptor binding
GO:0005132 type I interferon receptor binding
Biological Process
GO:0002250 adaptive immune response
GO:0002286 T cell activation involved in immune response
GO:0002312 B cell activation involved in immune response
GO:0002323 natural killer cell activation involved in immune response
GO:0006952 defense response
GO:0006959 humoral immune response
GO:0007166 cell surface receptor signaling pathway
GO:0007596 blood coagulation
GO:0009615 response to virus
GO:0019221 cytokine-mediated signaling pathway
GO:0030101 natural killer cell activation
GO:0030183 B cell differentiation
GO:0033141 positive regulation of peptidyl-serine phosphorylation of STAT protein
GO:0035458 cellular response to interferon-beta
GO:0042100 B cell proliferation
GO:0042742 defense response to bacterium
GO:0043330 response to exogenous dsRNA
GO:0045071 negative regulation of viral genome replication
GO:0045087 innate immune response (InnateDB)
GO:0045089 positive regulation of innate immune response
GO:0045343 regulation of MHC class I biosynthetic process
GO:0045581 negative regulation of T cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051607 defense response to virus
GO:0060337 type I interferon signaling pathway
GO:0060338 regulation of type I interferon-mediated signaling pathway
GO:0071359 cellular response to dsRNA
GO:0071360 cellular response to exogenous dsRNA
GO:2000552 negative regulation of T-helper 2 cell cytokine production
GO:2001235 positive regulation of apoptotic signaling pathway
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
Orthologs
Species
Mus musculus
Gene ID
Gene Order
Method
Confidence
Comments
Low
Tentative data, uncurated. RBBH derived.
Pathways
NETPATH
REACTOME
Cellular responses to stress pathway
Interferon alpha/beta signaling pathway
Cytokine Signaling in Immune system pathway
Innate Immune System pathway
TRAF6 mediated IRF7 activation pathway
Regulation of IFNA signaling pathway
RIG-I/MDA5 mediated induction of IFN-alpha/beta pathways pathway
Interferon Signaling pathway
Immune System pathway
TRAF3-dependent IRF activation pathway pathway
Cellular Senescence pathway
Factors involved in megakaryocyte development and platelet production pathway
Oxidative Stress Induced Senescence pathway
Hemostasis pathway
KEGG
Cytokine-cytokine receptor interaction pathway
Osteoclast differentiation pathway
Toll-like receptor signaling pathway pathway
RIG-I-like receptor signaling pathway pathway
Cytosolic DNA-sensing pathway pathway
Jak-STAT signaling pathway pathway
Natural killer cell mediated cytotoxicity pathway
Chagas disease (American trypanosomiasis) pathway
Hepatitis C pathway
INOH
GPCR signaling pathway
JAK STAT pathway and regulation pathway
PID BIOCARTA
The information processing pathway at the ifn beta enhancer [Biocarta view]
Ifn alpha signaling pathway [Biocarta view]
Bone remodeling [Biocarta view]
Double stranded rna induced gene expression [Biocarta view]
Signal transduction through il1r [Biocarta view]
PID NCI
Regulation of nuclear SMAD2/3 signaling
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.93177
RefSeq NM_002176
HUGO
OMIM
CCDS CCDS6495
HPRD 00972
IMGT
EMBL
GenPept
RNA Seq Atlas