Version 5.4
Homo sapiens Gene: ARSI
Summary
InnateDB Gene IDBG-53501.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARSI
Gene Name arylsulfatase family, member I
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183876
Encoded Proteins
IDBP-53503
arylsulfatase family, member I
IDBP-475399
arylsulfatase family, member I
IDBP-477907
arylsulfatase family, member I
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Sulfatases (EC 3.1.5.6), such as ARSI, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:150296343-150339307
Strand Reverse strand
Band q32
Transcripts
ENST00000328668 ENSP00000333395
ENST00000515301 ENSP00000426879
ENST00000509146 ENSP00000420955
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004065 arylsulfatase activity
GO:0008484 sulfuric ester hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0008152 metabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000036412
View Gene Order
ENSBTAG00000012834
Not yet available
Pathways
NETPATH
REACTOME
REACT_121036
The activation of arylsulfatases pathway
REACT_116105
Glycosphingolipid metabolism pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_1069
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_17015
Metabolism of proteins pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q5FYB1
TrEMBL D6RDH0
UniProt Splice Variant
Entrez Gene 340075
UniGene Hs.591252
RefSeq NM_001012301
HUGO HGNC:32521
OMIM 610009
CCDS CCDS34275
HPRD 16510
IMGT
EMBL AB448735 AC011372 AK122641 AY875937 BC129995 BC129996
GenPept AAI29996 AAI29997 AAW66665 BAG53634 BAH11166
RNA Seq Atlas 340075

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca