Version 5.4
Homo sapiens Gene: KCNK4
Summary
InnateDB Gene IDBG-53522.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol KCNK4
Gene Name potassium channel, subfamily K, member 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000182450
Encoded Proteins
IDBP-241432
potassium channel, subfamily K, member 4
IDBP-377180
potassium channel, subfamily K, member 4
IDBP-588530
potassium channel, subfamily K, member 4
IDBP-586181
potassium channel, subfamily K, member 4
IDBP-596559
potassium channel, subfamily K, member 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Potassium channels play a role in many cellular processes including maintenance of the action potential, muscle contraction, hormone secretion, osmotic regulation, and ion flow. This gene encodes one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The encoded protein homodimerizes and functions as an outwardly rectifying channel. It is expressed primarily in neural tissues and is stimulated by membrane stretch and polyunsaturated fatty acids. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:64291302-64300031
Strand Forward strand
Band q13.1
Transcripts
ENST00000394525 ENSP00000378033
ENST00000422670 ENSP00000402797
ENST00000453423
ENST00000538846
ENST00000538767 ENSP00000446454
ENST00000539651
ENST00000541349 ENSP00000441460
ENST00000545838
ENST00000539216 ENSP00000444948
ENST00000536690
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005216 ion channel activity
GO:0005244 voltage-gated ion channel activity
GO:0005267 potassium channel activity
Biological Process
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0007268 synaptic transmission
GO:0034765 regulation of ion transmembrane transport
GO:0055085 transmembrane transport
GO:0071805 potassium ion transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000024957
View Gene Order
ENSBTAG00000008644
Not yet available
Pathways
NETPATH
REACTOME
REACT_75819
TWIK related potassium channel (TREK) pathway
REACT_75897
Tandem pore domain potassium channels pathway
REACT_13685
Neuronal System pathway
REACT_75908
Potassium Channels pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.647233
RefSeq NM_033310
HUGO
OMIM
CCDS CCDS8067
HPRD 12037
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca