InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PAK7

Summary

InnateDB Gene

IDBG-53557.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAK7

Gene Name

p21 protein (Cdc42/Rac)-activated kinase 7

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000101349

Encoded Proteins

IDBP-53559

p21 protein (Cdc42/Rac)-activated kinase 7

IDBP-53561

p21 protein (Cdc42/Rac)-activated kinase 7

IDBP-53563

p21 protein (Cdc42/Rac)-activated kinase 7

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is a member of the PAK family of Ser/Thr protein kinases. PAK family members are known to be effectors of Rac/Cdc42 GTPases, which have been implicated in the regulation of cytoskeletal dynamics, proliferation, and cell survival signaling. This kinase contains a CDC42/Rac1 interactive binding (CRIB) motif, and has been shown to bind CDC42 in the presence of GTP. This kinase is predominantly expressed in brain. It is capable of promoting neurite outgrowth, and thus may play a role in neurite development. This kinase is associated with microtubule networks and induces microtubule stabilization. The subcellular localization of this kinase is tightly regulated during cell cycle progression. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 20:9537389-9839041

Strand

Reverse strand

Band

p12.2

Transcripts

ENST00000378429	ENSP00000367686
ENST00000353224	ENSP00000322957
ENST00000378423	ENSP00000367679

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.

Experimentally validated
Total	14 [view]
Protein-Protein	14 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0006468	protein phosphorylation
GO:0006915	apoptotic process
GO:0007010	cytoskeleton organization
GO:0007165	signal transduction
GO:0007612	learning
GO:0007613	memory
GO:0007626	locomotory behavior
GO:0008283	cell proliferation
GO:0016049	cell growth
GO:0016477	cell migration
GO:0023014	signal transduction by phosphorylation
GO:2001237	negative regulation of extrinsic apoptotic signaling pathway

Cellular Component

GO:0005634	nucleus
GO:0005739	mitochondrion

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000039913

View Gene Order

ENSBTAG00000017679

Not yet available

Pathways

NETPATH

REACTOME

REACT_19226

Activation of Rac pathway

REACT_19351

Signaling by Robo receptor pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

hsa04810

Regulation of actin cytoskeleton pathway

hsa04012

ErbB signaling pathway pathway

hsa05211

Renal cell carcinoma pathway

hsa04360

Axon guidance pathway

hsa04510

Focal adhesion pathway

hsa04660

T cell receptor signaling pathway pathway

INOH

INOH website

IL-7 signaling pathway

INOH website

JAK STAT pathway and regulation pathway

INOH website

EPO signaling pathway pathway

INOH website

VEGF signaling pathway pathway

PID NCI

Cross-References

SwissProt

Q9P286

TrEMBL

Q9UJQ0

UniProt Splice Variant

Entrez Gene

57144

UniGene

Hs.32539

RefSeq

NM_020341 NM_177990 XM_005260766 XM_006723597

HUGO

HGNC:15916

OMIM

608038

CCDS

CCDS13107

HPRD

IMGT

EMBL

AB033090 AB040812 AK291401 AL031652 AL133002 AL135935 AL353612 CH471133

GenPept

BAA86578 BAA94194 BAF84090 CAB61350 CAH71126 CAI23529 CAI42211 EAX10358 EAX10359 EAX10360

RNA Seq Atlas

57144