InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: STAB2

Summary

InnateDB Gene

IDBG-53819.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

STAB2

Gene Name

stabilin 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000136011

Encoded Proteins

IDBP-53825

stabilin 2

IDBP-598170

stabilin 2

IDBP-598667

stabilin 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a large, transmembrane receptor protein which may function in angiogenesis, lymphocyte homing, cell adhesion, or receptor scavenging. The protein contains 7 fasciclin, 15 epidermal growth factor (EGF)-like, and 2 laminin-type EGF-like domains as well as a C-type lectin-like hyaluronan-binding Link module. The protein is primarily expressed on sinusoidal endothelial cells of liver, spleen, and lymph node. The receptor has been shown to bind and endocytose ligands such as hyaluronan, low density lipoprotein, Gram-positive and Gram-negative bacteria, and advanced glycosylation end products. Supporting its possible role as a scavenger receptor, the protein has been shown to cycle between the plasma membrane and lysosomes. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:103587273-103766727

Strand

Forward strand

Band

q23.3

Transcripts

ENST00000388887	ENSP00000373539
ENST00000549474	ENSP00000449282
ENST00000549798
ENST00000548073
ENST00000548579
ENST00000552777	ENSP00000446629

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.

Experimentally validated
Total	10 [view]
Protein-Protein	10 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005041	low-density lipoprotein receptor activity
GO:0005044	scavenger receptor activity
GO:0005509	calcium ion binding
GO:0005515	protein binding
GO:0005540	hyaluronic acid binding
GO:0015035	protein disulfide oxidoreductase activity
GO:0030169	low-density lipoprotein particle binding

Biological Process

GO:0001525	angiogenesis
GO:0005975	carbohydrate metabolic process
GO:0006897	endocytosis
GO:0006898	receptor-mediated endocytosis
GO:0007155	cell adhesion
GO:0010468	regulation of gene expression
GO:0030193	regulation of blood coagulation
GO:0030203	glycosaminoglycan metabolic process
GO:0030212	hyaluronan metabolic process
GO:0030214	hyaluronan catabolic process
GO:0042742	defense response to bacterium
GO:0044281	small molecule metabolic process
GO:0055114	oxidation-reduction process

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0030666	endocytic vesicle membrane