Version 5.4
Homo sapiens Gene: NUDT5
Summary
InnateDB Gene IDBG-53844.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NUDT5
Gene Name nudix (nucleoside diphosphate linked moiety X)-type motif 5
Synonyms hYSAH1; YSA1; YSA1H; YSAH1
Species Homo sapiens
Ensembl Gene ENSG00000165609
Encoded Proteins
IDBP-53848
nudix (nucleoside diphosphate linked moiety X)-type motif 5
IDBP-53850
nudix (nucleoside diphosphate linked moiety X)-type motif 5
IDBP-53854
nudix (nucleoside diphosphate linked moiety X)-type motif 5
IDBP-365715
nudix (nucleoside diphosphate linked moiety X)-type motif 5
IDBP-480002
nudix (nucleoside diphosphate linked moiety X)-type motif 5
IDBP-603515
nudix (nucleoside diphosphate linked moiety X)-type motif 5
IDBP-590373
nudix (nucleoside diphosphate linked moiety X)-type motif 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Nudix hydrolases, such as NUDT5, eliminate toxic nucleotide derivatives from the cell and regulate the levels of important signaling nucleotides and their metabolites (McLennan, 1999 [PubMed 10373642]).[supplied by OMIM, Mar 2008]
This gene belongs to the Nudix (nucleoside diphosphate linked moiety X) hydrolase superfamily. The encoded enzyme catalyzes the hydrolysis of modified nucleoside diphosphates, including ADP-ribose (ADPR) and 8-oxoGua-containing 8-oxo-dADP and 8-oxo-dGDP. Protein-bound ADP ribose can be hazardous to the cell because it can modify some amino acid residues, resulting in the inhibition of ATP-activated potassium channels. 8-oxoGua is an oxidized form of guanine that can potentially alter genetic information by pairing with adenine and cytosine in RNA. Presence of 8-oxoGua in RNA results in formation of abnormal proteins due to translational errors. [provided by RefSeq, Aug 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 10:12165325-12196144
Strand Reverse strand
Band p14
Transcripts
ENST00000378952
ENST00000378940 ENSP00000368222
ENST00000378937 ENSP00000368219
ENST00000378927 ENSP00000368209
ENST00000444732 ENSP00000407856
ENST00000491614 ENSP00000419628
ENST00000476462 ENSP00000436844
ENST00000498825
ENST00000537776 ENSP00000445116
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 14 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 14 [view]
Protein-Protein 13 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000287 magnesium ion binding
GO:0016787 hydrolase activity
GO:0017110 nucleoside-diphosphatase activity
GO:0019144 ADP-sugar diphosphatase activity
GO:0030515 snoRNA binding
GO:0047631 ADP-ribose diphosphatase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0008152 metabolic process
GO:0009117 nucleotide metabolic process
GO:0009191 ribonucleoside diphosphate catabolic process
GO:0019303 D-ribose catabolic process
GO:0034656 nucleobase-containing small molecule catabolic process
GO:0044281 small molecule metabolic process
GO:0055086 nucleobase-containing small molecule metabolic process
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005829 cytosol
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000025817
View Gene Order
ENSBTAG00000019509
Not yet available
Pathways
NETPATH
REACTOME
REACT_150237
Phosphate bond hydrolysis by NUDT proteins pathway
REACT_1698
Metabolism of nucleotides pathway
REACT_111217
Metabolism pathway
KEGG
hsa00230
Purine metabolism pathway
INOH
INOH website
Purine nucleotides nucleosides metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.674337
RefSeq NM_014142
HUGO
OMIM
CCDS CCDS7089
HPRD 14851
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca