Homo sapiens Gene: SLC12A6
Summary
InnateDB Gene IDBG-5416.5
Last Modified 2012-02-14 [Report errors or provide feedback]
Gene Symbol SLC12A6
Gene Name solute carrier family 12 (potassium/chloride transporters), member 6
Synonyms ACCPN; KCC3; KCC3A; KCC3B;
Species Homo sapiens
Ensembl Gene ENSG00000140199
Encoded Proteins
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
solute carrier family 12 (potassium/chloride transporters), member 6
Protein Structure
Entrez Gene
Summary This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:34525460-34630261
Strand Reverse strand
Band q14
Transcripts
ENST00000354181 ENSP00000346112
ENST00000290209 ENSP00000290209
ENST00000397707 ENSP00000380819
ENST00000397702 ENSP00000380814
ENST00000458406 ENSP00000387725
ENST00000451844 ENSP00000390199
ENST00000560611 ENSP00000454168
ENST00000559523 ENSP00000452904
ENST00000559664 ENSP00000453702
ENST00000560164 ENSP00000452705
ENST00000561080 ENSP00000454069
ENST00000558667 ENSP00000453473
ENST00000558589 ENSP00000452776
ENST00000559076
ENST00000559441
ENST00000558950
ENST00000560023
ENST00000560332 ENSP00000454037
ENST00000561120 ENSP00000452771
ENST00000559236 ENSP00000452828
ENST00000559484 ENSP00000452857
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0015377 cation:chloride symporter activity
GO:0015379 potassium:chloride symporter activity
Biological Process
GO:0001525 angiogenesis
GO:0006810 transport
GO:0006811 ion transport
GO:0006813 potassium ion transport
GO:0055085 transmembrane transport
GO:0071477 cellular hypotonic salinity response
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016021 integral to membrane
GO:0016323 basolateral plasma membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
REACTOME
Cation-coupled Chloride cotransporters pathway
KEGG
INOH
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9UHW9
TrEMBL B3KXX3 H0YKE6 H0YKJ2 H0YKL8 H0YKQ8 H0YMQ9 H0YNJ5
UniProt Splice Variant
Entrez Gene 9990
UniGene Hs.510939
RefSeq NM_001042494 NM_001042495 NM_001042496 NM_001042497 NM_005135 NM_133647
HUGO 10914
OMIM 604878
CCDS CCDS10036 CCDS42010 CCDS42011 CCDS42012
HPRD 09220
IMGT
EMBL AC021822 AC079203 AF105366 AF108831 AF116242 AF314931 AF314932 AF314933 AF314934 AF314935 AF314936 AF314937 AF314938 AF314939 AF314940 AF314941 AF314942 AF314943 AF314944 AF314945 AF314946 AF314947 AF314948 AF314949 AF314950 AF314951 AF314952 AF314953 AF314954 AF314955 AF314956 AF477977 AF531258 AF531259 AF531260 AK128133 AK315283 AL117500 BC126241 BC126243 CH471125 DQ138323
GenPept AAD25337 AAD39742 AAF24986 AAI26242 AAI26244 AAL85335 AAM96215 AAM96216 AAQ10026 AAQ10027 AAQ10028 ABA02873 BAG37692 BAG54635 CAB55965 EAW92295 EAW92297 EAW92298 EAW92301
ImmGen SLC12A6 (murine)
RNA Seq Atlas 9990