InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RAB1A

Summary

InnateDB Gene

IDBG-54165.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RAB1A

Gene Name

RAB1A, member RAS oncogene family

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000138069

Encoded Proteins

IDBP-232867

RAB1A, member RAS oncogene family

IDBP-292924

RAB1A, member RAS oncogene family

IDBP-292925

RAB1A, member RAS oncogene family

IDBP-292919

RAB1A, member RAS oncogene family

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of the Ras superfamily of GTPases. Members of the gene family cycle between inactive GDP-bound and active GTP-bound forms. This small GTPase controls vesicle traffic from the endoplasmic reticulum to the Golgi apparatus. Multiple alternatively spliced transcript variants have been identified for this gene which encode different protein isoforms. [provided by RefSeq, Oct 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:65070701-65130106

Strand

Reverse strand

Band

p14

Transcripts

ENST00000398529	ENSP00000381540
ENST00000409784	ENSP00000387286
ENST00000409892	ENSP00000386451
ENST00000409751	ENSP00000386672
ENST00000494188

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 64 experimentally validated interaction(s) in this database.

Experimentally validated
Total	64 [view]
Protein-Protein	64 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003924	GTPase activity
GO:0005515	protein binding
GO:0005525	GTP binding

Biological Process

GO:0000045	autophagic vacuole assembly
GO:0000278	mitotic cell cycle
GO:0006184	GTP catabolic process
GO:0006886	intracellular protein transport
GO:0006888	ER to Golgi vesicle-mediated transport
GO:0006897	endocytosis
GO:0006913	nucleocytoplasmic transport
GO:0006914	autophagy
GO:0007165	signal transduction
GO:0007264	small GTPase mediated signal transduction
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0016477	cell migration
GO:0030252	growth hormone secretion
GO:0032402	melanosome transport
GO:0034446	substrate adhesion-dependent cell spreading
GO:0042742	defense response to bacterium
GO:0047496	vesicle transport along microtubule
GO:0072606	interleukin-8 secretion

Cellular Component

GO:0000139	Golgi membrane
GO:0005622	intracellular
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005769	early endosome
GO:0005783	endoplasmic reticulum
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0016020	membrane
GO:0042470	melanosome
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000020149

View Gene Order

ENSBTAG00000016720

Not yet available

Pathways

NETPATH

REACTOME

REACT_1100

Golgi Cisternae Pericentriolar Stack Reorganization pathway

REACT_115566

Cell Cycle pathway

REACT_910

M Phase pathway

REACT_765

Mitotic Prophase pathway

REACT_152

Cell Cycle, Mitotic pathway

KEGG

INOH

PID NCI

plk1_pathway

PLK1 signaling events

Cross-References

SwissProt

P62820

TrEMBL

UniProt Splice Variant

Entrez Gene

5861

UniGene

Hs.696354

RefSeq

NM_015543 NM_004161

HUGO

HGNC:9758

OMIM

179508

CCDS

CCDS46305 CCDS46306

HPRD

01538

IMGT

EMBL

AF498929 AK055927 AL050268 BC000905 BX571747 CH471053 CR533479 M28209

GenPept

AAA60240 AAH00905 AAM21077 BAB71048 CAB43369 CAE11872 CAG38510 EAW99921

RNA Seq Atlas

5861