Version 5.4
Homo sapiens Gene: ADAM11
Summary
InnateDB Gene IDBG-54231.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ADAM11
Gene Name ADAM metallopeptidase domain 11
Synonyms MDC
Species Homo sapiens
Ensembl Gene ENSG00000073670
Encoded Proteins
IDBP-54233
ADAM metallopeptidase domain 11
IDBP-54235
ADAM metallopeptidase domain 11
IDBP-596668
ADAM metallopeptidase domain 11
IDBP-762484
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the ADAM (a disintegrin and metalloprotease) protein family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This gene represents a candidate tumor supressor gene for human breast cancer based on its location within a minimal region of chromosome 17q21 previously defined by tumor deletion mapping. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:44759031-44781846
Strand Forward strand
Band q21.31
Transcripts
ENST00000355638 ENSP00000347856
ENST00000200557 ENSP00000200557
ENST00000535346 ENSP00000443773
ENST00000587773 ENSP00000465537
ENST00000588363
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004222 metalloendopeptidase activity
GO:0005178 integrin binding
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
GO:0007229 integrin-mediated signaling pathway
Cellular Component
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0031012 extracellular matrix
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020926
View Gene Order
ENSBTAG00000001735
Not yet available
Cross-References
SwissProt
TrEMBL B4DKD2
UniProt Splice Variant
Entrez Gene 4185
UniGene Hs.6088
RefSeq NM_002390
HUGO HGNC:189
OMIM 155120
CCDS CCDS11486
HPRD 01114
IMGT
EMBL AC005180 AK296512
GenPept BAG59144
RNA Seq Atlas 4185

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca