InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: GJC1

Summary

InnateDB Gene

IDBG-54323.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

GJC1

Gene Name

gap junction protein, gamma 1, 45kDa

Synonyms

CX45; GJA7

Species

Homo sapiens

Ensembl Gene

ENSG00000182963

Encoded Proteins

IDBP-54325

gap junction protein, gamma 1, 45kDa

IDBP-379750

gap junction protein, gamma 1, 45kDa

IDBP-759564

IDBP-763950

IDBP-759217

IDBP-759215

IDBP-764228

IDBP-762071

IDBP-763366

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Alternatively spliced transcript variants encoding the same isoform have been described. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:44798448-44830816

Strand

Reverse strand

Band

q21.31

Transcripts

ENST00000330514	ENSP00000333193
ENST00000426548	ENSP00000411528
ENST00000592524	ENSP00000467201
ENST00000587113	ENSP00000468716
ENST00000587239	ENSP00000467626
ENST00000586347	ENSP00000468258
ENST00000586267	ENSP00000467090
ENST00000591424	ENSP00000466392
ENST00000590758	ENSP00000466339

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	4 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005243	gap junction channel activity
GO:0005515	protein binding

Biological Process

GO:0001570	vasculogenesis
GO:0006810	transport
GO:0006936	muscle contraction
GO:0007043	cell-cell junction assembly
GO:0007267	cell-cell signaling
GO:0007268	synaptic transmission
GO:0007507	heart development
GO:0007601	visual perception
GO:0016264	gap junction assembly
GO:0034220	ion transmembrane transport
GO:0048468	cell development
GO:0048738	cardiac muscle tissue development
GO:0055085	transmembrane transport
GO:0061024	membrane organization
GO:0086014	atrial cardiac muscle cell action potential

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005921	gap junction
GO:0005922	connexon complex
GO:0014704	intercalated disc
GO:0016021	integral component of membrane

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000034520

View Gene Order

ENSBTAG00000004036

Not yet available

Pathways

NETPATH

REACTOME

REACT_9509

Gap junction assembly pathway

REACT_16970

Electric Transmission Across Gap Junctions pathway

REACT_13685

Neuronal System pathway

REACT_16881

Transmission across Electrical Synapses pathway

REACT_9411

Gap junction trafficking pathway

REACT_9480

Gap junction trafficking and regulation pathway

REACT_11123

Membrane Trafficking pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.532593 Hs.740882

RefSeq

NM_001080383 NM_005497 XM_005256920

HUGO

OMIM

CCDS

CCDS11487

HPRD

08819

IMGT

EMBL

GenPept

RNA Seq Atlas