Version 5.4
Homo sapiens Gene: C1D
Summary
InnateDB Gene IDBG-54438.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol C1D
Gene Name C1D nuclear receptor corepressor
Synonyms hC1D; LRP1; SUN-CoR; SUNCOR
Species Homo sapiens
Ensembl Gene ENSG00000197223
Encoded Proteins
IDBP-54440
C1D nuclear receptor corepressor
IDBP-295728
C1D nuclear receptor corepressor
IDBP-295723
C1D nuclear receptor corepressor
IDBP-295726
C1D nuclear receptor corepressor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:68041130-68110948
Strand Reverse strand
Band p14
Transcripts
ENST00000355848 ENSP00000348107
ENST00000407324 ENSP00000384304
ENST00000410067 ENSP00000386468
ENST00000409302 ENSP00000386779
ENST00000479484
ENST00000485709
ENST00000470189
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 16 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 16 [view]
Protein-Protein 15 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003714 transcription corepressor activity
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0016922 ligand-dependent nuclear receptor binding
Biological Process
GO:0000460 maturation of 5.8S rRNA
GO:0006351 transcription, DNA-templated
GO:0006915 apoptotic process
GO:0045892 negative regulation of transcription, DNA-templated
Cellular Component
GO:0000176 nuclear exosome (RNase complex)
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0017053 transcriptional repressor complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000000581
View Gene Order
ENSBTAG00000004567
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03018
RNA degradation pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.436242 Hs.602900
RefSeq NM_001190263 NM_001190265 NM_006333 NM_173177
HUGO
OMIM
CCDS CCDS1883
HPRD 07382
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca