Version 5.4
Homo sapiens Gene: SLC36A2
Summary
InnateDB Gene IDBG-54441.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC36A2
Gene Name solute carrier family 36 (proton/amino acid symporter), member 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000186335
Encoded Proteins
IDBP-54443
solute carrier family 36 (proton/amino acid symporter), member 2
IDBP-475185
solute carrier family 36 (proton/amino acid symporter), member 2
IDBP-477760
solute carrier family 36 (proton/amino acid symporter), member 2
IDBP-479436
solute carrier family 36 (proton/amino acid symporter), member 2
IDBP-485087
solute carrier family 36 (proton/amino acid symporter), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a pH-dependent proton-coupled amino acid transporter that belongs to the amino acid auxin permease 1 protein family. The encoded protein primarily transports small amino acids such as glycine, alanine and proline. Mutations in this gene are associated with iminoglycinuria and hyperglycinuria. [provided by RefSeq, Sep 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:151314978-151347590
Strand Reverse strand
Band q33.1
Transcripts
ENST00000335244 ENSP00000334223
ENST00000518617 ENSP00000430149
ENST00000518280 ENSP00000428453
ENST00000521967 ENSP00000430535
ENST00000523044 ENSP00000428634
ENST00000522829
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005280 hydrogen:amino acid symporter activity
GO:0015180 L-alanine transmembrane transporter activity
GO:0015187 glycine transmembrane transporter activity
GO:0015193 L-proline transmembrane transporter activity
Biological Process
GO:0006811 ion transport
GO:0006865 amino acid transport
GO:0015808 L-alanine transport
GO:0015816 glycine transport
GO:0015824 proline transport
GO:0015992 proton transport
GO:0035524 proline transmembrane transport
GO:0055085 transmembrane transport
Cellular Component
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020264
View Gene Order
ENSBTAG00000020809
Not yet available
Pathways
NETPATH
REACTOME
REACT_19348
Proton-coupled neutral amino acid transporters pathway
REACT_13796
Amino acid transport across the plasma membrane pathway
REACT_19397
Transport of inorganic cations/anions and amino acids/oligopeptides pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.483877
RefSeq NM_181776 XM_005268377
HUGO
OMIM
CCDS CCDS4315
HPRD 12215
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca