Version 5.4
Homo sapiens Gene: SALL3
Summary
InnateDB Gene IDBG-544745.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SALL3
Gene Name sal-like 3 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000256463
Encoded Proteins
IDBP-593046
sal-like 3 (Drosophila)
IDBP-583127
sal-like 3 (Drosophila)
IDBP-725591
IDBP-726788
IDBP-812426
spalt-like transcription factor 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a sal-like C2H2-type zinc-finger protein, and belongs to a family of evolutionarily conserved genes found in species as diverse as Drosophila, C. elegans, and vertebrates. Mutations in some of these genes are associated with congenital disorders in human, suggesting their importance in embryonic development. This protein binds to DNA methyltransferase 3 alpha (DNMT3A), and reduces DNMT3A-mediated CpG island methylation. It is suggested that silencing of this gene, resulting in acceleration of DNA methylation, may have a role in oncogenesis. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 18:78980275-79002677
Strand Forward strand
Band q23
Transcripts
ENST00000537592 ENSP00000441823
ENST00000536229 ENSP00000439975
ENST00000575389 ENSP00000458360
ENST00000573324 ENSP00000461451
ENST00000572928
ENST00000616649 ENSP00000481352
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0021891 olfactory bulb interneuron development
GO:0035136 forelimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0045879 negative regulation of smoothened signaling pathway
Cellular Component
GO:0005634 nucleus
Orthologs
No orthologs found for this gene
Cross-References
SwissProt Q9BXA9
TrEMBL
UniProt Splice Variant
Entrez Gene 27164
UniGene Hs.700557 Hs.713962
RefSeq NM_171999
HUGO HGNC:10527
OMIM 605079
CCDS CCDS12013
HPRD
IMGT
EMBL AC099689 AF347021 AJ007421
GenPept AAK18311 CAB65124
RNA Seq Atlas 27164

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca