InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NFATC1

Summary

InnateDB Gene

IDBG-5452.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NFATC1

Gene Name

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

Synonyms

NF-ATC; NFAT2; NFATc

Species

Homo sapiens

Ensembl Gene

ENSG00000131196

Encoded Proteins

IDBP-5454

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

IDBP-5456

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

IDBP-5458

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

IDBP-234560

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

IDBP-372900

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

IDBP-591208

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

IDBP-602125

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 1

IDBP-725671

IDBP-726158

IDBP-725740

IDBP-726337

IDBP-727598

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Five transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2008]
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component. Proteins belonging to this family of transcription factors play a central role in inducible gene transcription during immune response. The product of this gene is an inducible nuclear component. It functions as a major molecular target for the immunosuppressive drugs such as cyclosporin A. Multiple alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. Different isoforms of this protein may regulate inducible expression of different cytokine genes. [provided by RefSeq, Jul 2013]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 18:79395856-79529325

Strand

Forward strand

Band

q23

Transcripts

ENST00000253506	ENSP00000253506
ENST00000318065	ENSP00000316553
ENST00000329101	ENSP00000327850
ENST00000397790	ENSP00000380892
ENST00000427363	ENSP00000389377
ENST00000542384	ENSP00000442435
ENST00000545796	ENSP00000439992
ENST00000590224
ENST00000591089
ENST00000586695
ENST00000590172
ENST00000590313	ENSP00000467615
ENST00000586434	ENSP00000466489
ENST00000591814	ENSP00000466194
ENST00000591065
ENST00000592223	ENSP00000467181
ENST00000590861
ENST00000587635	ENSP00000468111

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 61 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	61 [view]
Protein-Protein	41 [view]
Protein-DNA	20 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000979	RNA polymerase II core promoter sequence-specific DNA binding
GO:0000980	RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001085	RNA polymerase II transcription factor binding
GO:0001205	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0003705	RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0005528	FK506 binding
GO:0043565	sequence-specific DNA binding
GO:0044212	transcription regulatory region DNA binding
GO:0048273	mitogen-activated protein kinase p38 binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0001837	epithelial to mesenchymal transition
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006816	calcium ion transport
GO:0007507	heart development
GO:0010628	positive regulation of gene expression
GO:0030316	osteoclast differentiation
GO:0035556	intracellular signal transduction
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0045087	innate immune response
GO:0045893	positive regulation of transcription, DNA-templated
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0000790	nuclear chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005667	transcription factor complex
GO:0005737	cytoplasm
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000033016

View Gene Order

ENSBTAG00000000656

Not yet available

Pathways

NETPATH

NetPath_11

TCR pathway

NetPath_21

RANKL pathway

REACTOME

REACT_172761

Ca2+ pathway pathway

REACT_172694

beta-catenin independent WNT signaling pathway

REACT_11045

Signaling by Wnt pathway

REACT_6802

Innate Immune System pathway

REACT_163936

Fc epsilon receptor (FCERI) signaling pathway

REACT_111102

Signal Transduction pathway

REACT_6900

Immune System pathway

REACT_163834

FCERI mediated Ca+2 mobilization pathway

KEGG

hsa04310

Wnt signaling pathway pathway

hsa04010

MAPK signaling pathway pathway

hsa04662

B cell receptor signaling pathway pathway

hsa04660

T cell receptor signaling pathway pathway

hsa04650

Natural killer cell mediated cytotoxicity pathway

hsa04380

Osteoclast differentiation pathway

INOH

PID NCI

cd8tcrdownstreampathway

Downstream signaling in na�ve CD8+ T cells

nfat_tfpathway

Calcineurin-regulated NFAT-dependent transcription in lymphocytes

reg_gr_pathway

Glucocorticoid receptor regulatory network

bcr_5pathway

BCR signaling pathway

nfat_3pathway

Role of Calcineurin-dependent NFAT signaling in lymphocytes

Cross-References

SwissProt

O95644

TrEMBL

UniProt Splice Variant

Entrez Gene

4772

UniGene

Hs.534074 Hs.739976

RefSeq

NM_172388 NM_001278669 NM_001278670 NM_001278672 NM_001278673 NM_001278675 NM_006162 NM_172387 NM_172389 NM_172390 XM_006722477 XM_006722478

HUGO

HGNC:7775

OMIM

600489

CCDS

CCDS12016 CCDS12015 CCDS32850 CCDS59326 CCDS59327 CCDS62467 CCDS62468 CCDS62469 CCDS62470 CCDS62471

HPRD

02729

IMGT

EMBL

AC018445 AC023090 BC104753 BC112243 CH471117 EU887559 EU887560 EU887561 EU887562 EU887563 EU887564 EU887565 EU887566 U08015 U59736 U80917 U80918 U80919

GenPept

AAA19601 AAC50869 AAD00450 AAD00451 AAD00452 AAI04754 AAI12244 ACG55579 ACG55580 ACG55581 ACG55582 ACG55583 ACG55584 ACG55585 ACG55586 EAW66621 EAW66622

RNA Seq Atlas

4772