Version 5.4
Homo sapiens Gene: POLR2M
Summary
InnateDB Gene IDBG-545520.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR2M
Gene Name polymerase (RNA) II (DNA directed) polypeptide M
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000255529
Encoded Proteins
IDBP-13766
glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
IDBP-13768
glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
IDBP-595561
glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
IDBP-601512
glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
IDBP-601447
glutamate receptor, ionotropic, N-methyl D-aspartate-like 1A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a subunit of RNA polymerase II, a protein complex that is responsible for synthesizing messenger RNA in eukaryotes. The encoded protein functions as a component of a specific form of RNA polymerase II termed Pol II(G). This protein may act as a negative regulator of activator-dependent transcription. Alternate splicing results in multiple transcript variants. Read-through transcription also exists between this gene and the neighboring upstream gene MYZAP (myocardial zonula adherens protein). [provided by RefSeq, Nov 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:57706629-57782762
Strand Forward strand
Band q21.3
Transcripts
ENST00000299638 ENSP00000299638
ENST00000380557 ENSP00000369930
ENST00000494490 ENSP00000433988
ENST00000464277 ENSP00000437015
ENST00000482852 ENSP00000432615
ENST00000464308
ENST00000562260
ENST00000567643
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 21 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003899 DNA-directed RNA polymerase activity
Biological Process
GO:0032774 RNA biosynthetic process
GO:0051685 maintenance of ER location
Cellular Component
GO:0005635 nuclear envelope
GO:0016591 DNA-directed RNA polymerase II, holoenzyme
GO:0043025 neuronal cell body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032199
View Gene Order
ENSBTAG00000040384
Not yet available
Cross-References
SwissProt
TrEMBL E9PP13
UniProt Splice Variant
Entrez Gene 81488
UniGene Hs.618302 Hs.669771 Hs.702937
RefSeq NM_001018102 NM_015532
HUGO HGNC:14862
OMIM 606485
CCDS CCDS32252 CCDS42045
HPRD 07575
IMGT
EMBL AC025271 AC090651
GenPept
RNA Seq Atlas 145781 81488

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca