Version 5.4
Homo sapiens Gene: ATOX1
Summary
InnateDB Gene IDBG-54595.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ATOX1
Gene Name ATX1 antioxidant protein 1 homolog (yeast)
Synonyms ATX1; HAH1
Species Homo sapiens
Ensembl Gene ENSG00000177556
Encoded Proteins
IDBP-54597
ATX1 antioxidant protein 1 homolog (yeast)
IDBP-477626
ATX1 antioxidant protein 1 homolog (yeast)
IDBP-475673
ATX1 antioxidant protein 1 homolog (yeast)
IDBP-484592
ATX1 antioxidant protein 1 homolog (yeast)
IDBP-482626
ATX1 antioxidant protein 1 homolog (yeast)
IDBP-478324
ATX1 antioxidant protein 1 homolog (yeast)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:151742316-151772532
Strand Reverse strand
Band q33.1
Transcripts
ENST00000313115 ENSP00000316854
ENST00000521264 ENSP00000429366
ENST00000520382 ENSP00000429982
ENST00000522145
ENST00000522314 ENSP00000430028
ENST00000524142 ENSP00000430598
ENST00000522710 ENSP00000429814
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005375 copper ion transmembrane transporter activity
GO:0005507 copper ion binding
GO:0016530 metallochaperone activity
GO:0016531 copper chaperone activity
GO:0032767 copper-dependent protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006825 copper ion transport
GO:0006878 cellular copper ion homeostasis
GO:0006979 response to oxidative stress
GO:0015680 intracellular copper ion transport
GO:0030001 metal ion transport
GO:0035434 copper ion transmembrane transport
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018585
View Gene Order
ENSBTAG00000008340
Not yet available
Pathways
NETPATH
REACTOME
REACT_120956
Cellular responses to stress pathway
REACT_172715
Detoxification of Reactive Oxygen Species pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O00244
TrEMBL E5RGN3 E5RIM7
UniProt Splice Variant
Entrez Gene 475
UniGene Hs.125213 Hs.618558 Hs.681736
RefSeq NM_004045
HUGO HGNC:798
OMIM 602270
CCDS CCDS47317
HPRD
IMGT
EMBL AC011374 AC091982 AK293063 AY165037 AY986502 BC112248 BC112250 BT009786 CH471062 U70660
GenPept AAC51227 AAI12249 AAI12251 AAN84554 AAP88788 AAX81411 BAF85752 EAW61663 EAW61664
RNA Seq Atlas 475

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca