InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NMT1

Summary

InnateDB Gene

IDBG-54611.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NMT1

Gene Name

N-myristoyltransferase 1

Synonyms

NMT

Species

Homo sapiens

Ensembl Gene

ENSG00000136448

Encoded Proteins

IDBP-54615

N-myristoyltransferase 1

IDBP-602359

N-myristoyltransferase 1

IDBP-761314

IDBP-764201

IDBP-757800

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:45051610-45109016

Strand

Forward strand

Band

q21.31

Transcripts

ENST00000258960	ENSP00000258960
ENST00000543908	ENSP00000439263
ENST00000588455
ENST00000590114
ENST00000588975
ENST00000587014
ENST00000587670
ENST00000591931
ENST00000587120
ENST00000592654	ENSP00000466827
ENST00000592782	ENSP00000468424
ENST00000590310
ENST00000585561	ENSP00000466777

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	41 [view]
Protein-Protein	41 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003824	catalytic activity
GO:0004379	glycylpeptide N-tetradecanoyltransferase activity
GO:0019107	myristoyltransferase activity

Biological Process

GO:0001701	in utero embryonic development
GO:0006499	N-terminal protein myristoylation
GO:0006915	apoptotic process
GO:0007603	phototransduction, visible light
GO:0009249	protein lipoylation
GO:0016032	viral process
GO:0016056	rhodopsin mediated signaling pathway
GO:0022400	regulation of rhodopsin mediated signaling pathway
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway