Version 5.4
Homo sapiens Gene: APLF
Summary
InnateDB Gene IDBG-54616.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol APLF
Gene Name aprataxin and PNKP like factor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000169621
Encoded Proteins
IDBP-54618
aprataxin and PNKP like factor
IDBP-378135
aprataxin and PNKP like factor
IDBP-592821
aprataxin and PNKP like factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary C2ORF13 is a component of the cellular response to chromosomal DNA single- and double-strand breaks (Iles et al., 2007 [PubMed 17353262]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:68467561-68655576
Strand Forward strand
Band p13.3
Transcripts
ENST00000303795 ENSP00000307004
ENST00000445692 ENSP00000393403
ENST00000471727
ENST00000488585
ENST00000529851 ENSP00000432297
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 19 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 19 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003906 DNA-(apurinic or apyrimidinic site) lyase activity
GO:0004520 endodeoxyribonuclease activity
GO:0004930 G-protein coupled receptor activity
GO:0004983 neuropeptide Y receptor activity
GO:0005515 protein binding
GO:0008408 3'-5' exonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0000012 single strand break repair
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006302 double-strand break repair
GO:0006974 cellular response to DNA damage stimulus
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007218 neuropeptide signaling pathway
GO:0045191 regulation of isotype switching
GO:0051106 positive regulation of DNA ligation
GO:0090305 nucleic acid phosphodiester bond hydrolysis
Cellular Component
GO:0005634 nucleus
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016021 integral component of membrane
GO:0035861 site of double-strand break
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030051
View Gene Order
ENSBTAG00000018401
Not yet available
Pathways
NETPATH
REACTOME
REACT_18283
G alpha (q) signalling events pathway
REACT_120966
Gastrin-CREB signalling pathway via PKC and MAPK pathway
REACT_14819
Peptide ligand-binding receptors pathway
REACT_14828
Class A/1 (Rhodopsin-like receptors) pathway
REACT_14797
Signaling by GPCR pathway
REACT_111102
Signal Transduction pathway
REACT_19184
GPCR downstream signaling pathway
REACT_21340
GPCR ligand binding pathway
KEGG
INOH
PID NCI
dnapk_pathway
DNA-PK pathway in nonhomologous end joining
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.720369 Hs.735377
RefSeq NM_138964 NM_173545
HUGO
OMIM
CCDS CCDS1888 CCDS1889
HPRD 09848
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca