Homo sapiens Gene: G3BP1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-54619.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | G3BP1 | ||||||||||||||||||||||
Gene Name | GTPase activating protein (SH3 domain) binding protein 1 | ||||||||||||||||||||||
Synonyms | G3BP; HDH-VIII | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000145907 | ||||||||||||||||||||||
Encoded Proteins |
GTPase activating protein (SH3 domain) binding protein 1
GTPase activating protein (SH3 domain) binding protein 1
GTPase activating protein (SH3 domain) binding protein 1
GTPase activating protein (SH3 domain) binding protein 1
GTPase activating protein (SH3 domain) binding protein 1
GTPase activating protein (SH3 domain) binding protein 1
GTPase activating protein (SH3 domain) binding protein 1
GTPase activating protein (SH3 domain) binding protein 1
GTPase activating protein (SH3 domain) binding protein 1
GTPase activating protein (SH3 domain) binding protein 1
GTPase activating protein (SH3 domain) binding protein 1
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
EIF2AK2 (PKR) is recruited to stress granules by G3BP1 to promote innate immune responses at both transcriptional and translational levels.
The G3BP1-CAPRIN1-PRKRA complex represents a new mode of PRKRA activation and links stress responses with innate immune activation through PRKRA without a requirement for foreign double-stranded RNA pattern recognition.
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Entrez Gene | |||||||||||||||||||||||
Summary |
This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] This gene encodes one of the DNA-unwinding enzymes which prefers partially unwound 3\'-tailed substrates and can also unwind partial RNA/DNA and RNA/RNA duplexes in an ATP-dependent fashion. This enzyme is a member of the heterogeneous nuclear RNA-binding proteins and is also an element of the Ras signal transduction pathway. It binds specifically to the Ras-GTPase-activating protein by associating with its SH3 domain. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:151771045-151812785 | ||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||
Band | q33.1 | ||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 116 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH |
KitReceptor pathway
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REACTOME | |||||||||||||||||||||||
KEGG | |||||||||||||||||||||||
INOH | |||||||||||||||||||||||
PID NCI | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.30980 Hs.3353 Hs.587054 Hs.595645 Hs.600794 Hs.660566 Hs.684144 Hs.699092 Hs.707858 | ||||||||||||||||||||||
RefSeq | NM_005754 NM_198395 XM_006714749 XM_006714750 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS4319 | ||||||||||||||||||||||
HPRD | 06569 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||