Homo sapiens Gene: ST20-MTHFS | |||||
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Summary | |||||
InnateDB Gene | IDBG-546521.3 | ||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||
Gene Symbol | ST20-MTHFS | ||||
Gene Name | ST20-MTHFS protein | ||||
Synonyms | |||||
Species | Homo sapiens | ||||
Ensembl Gene | ENSG00000259332 | ||||
Encoded Proteins | |||||
Protein Structure | |||||
Useful resources | Stemformatics EHFPI ImmGen | ||||
Entrez Gene | |||||
Summary |
This locus represents naturally occurring read-through transcription between the neighboring suppressor of tumorigenicity 20 and 5,10-methenyltetrahydrofolate synthetase (5-formyltetrahydrofolate cyclo-ligase) genes on chromosome 15. The read-through transcript produces a fusion protein that shares sequence identity with each individual gene product. [provided by RefSeq, Dec 2010] The protein encoded by this gene is an enzyme that catalyzes the conversion of 5-formyltetrahydrofolate to 5,10-methenyltetrahydrofolate, a precursor of reduced folates involved in 1-carbon metabolism. An increased activity of the encoded protein can result in an increased folate turnover rate and folate depletion. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2011] |
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Gene Information | |||||
Type | Protein coding | ||||
Genomic Location | Chromosome 15:79845195-79923754 | ||||
Strand | Reverse strand | ||||
Band | q25.1 | ||||
Transcripts |
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Interactions | |||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Orthologs | |||||
No orthologs found for this gene | |||||
Pathways | |||||
NETPATH | |||||
REACTOME | |||||
KEGG |
One carbon pool by folate pathway
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INOH | |||||
PID NCI | |||||
Cross-References | |||||
SwissProt | |||||
TrEMBL | |||||
UniProt Splice Variant | |||||
Entrez Gene | 10588 | ||||
UniGene | |||||
RefSeq | NM_001199760 | ||||
HUGO | HGNC:44655 | ||||
OMIM | 604197 | ||||
CCDS | CCDS58394 | ||||
HPRD | |||||
IMGT | |||||
EMBL | |||||
GenPept | |||||
RNA Seq Atlas | 100528021 10588 | ||||