Version 5.4
Homo sapiens Gene: BMP10
Summary
InnateDB Gene IDBG-54663.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol BMP10
Gene Name bone morphogenetic protein 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000163217
Encoded Proteins
IDBP-54665
bone morphogenetic protein 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the TGF-beta family of growth factors. Data suggest that the similar protein in mouse plays an important role in trabeculation of the embryonic heart. In human, this protein may signal through receptor serine/threonine kinases. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:68865481-68871517
Strand Reverse strand
Band p13.3
Transcripts
ENST00000295379 ENSP00000295379
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005125 cytokine activity
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0008083 growth factor activity
GO:0033612 receptor serine/threonine kinase binding
Biological Process
GO:0007155 cell adhesion
GO:0007507 heart development
GO:0007512 adult heart development
GO:0010596 negative regulation of endothelial cell migration
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010614 negative regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0010862 positive regulation of pathway-restricted SMAD protein phosphorylation
GO:0014898 cardiac muscle hypertrophy in response to stress
GO:0030198 extracellular matrix organization
GO:0030308 negative regulation of cell growth
GO:0030336 negative regulation of cell migration
GO:0030509 BMP signaling pathway
GO:0032924 activin receptor signaling pathway
GO:0040007 growth
GO:0045214 sarcomere organization
GO:0045893 positive regulation of transcription, DNA-templated
GO:0055009 atrial cardiac muscle tissue morphogenesis
GO:0055010 ventricular cardiac muscle tissue morphogenesis
GO:0055015 ventricular cardiac muscle cell development
GO:0055117 regulation of cardiac muscle contraction
GO:0060038 cardiac muscle cell proliferation
GO:0060045 positive regulation of cardiac muscle cell proliferation
GO:0060298 positive regulation of sarcomere organization
GO:0060347 heart trabecula formation
GO:0060389 pathway-restricted SMAD protein phosphorylation
GO:2000138 positive regulation of cell proliferation involved in heart morphogenesis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0009986 cell surface
GO:0030018 Z disc
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030046
View Gene Order
ENSBTAG00000000992
Not yet available
Pathways
NETPATH
REACTOME
REACT_150331
Molecules associated with elastic fibres pathway
REACT_150366
Elastic fibre formation pathway
REACT_118779
Extracellular matrix organization pathway
KEGG
INOH
INOH website
GPCR signaling pathway
INOH website
TGF-beta signaling pathway
INOH website
BMP2 signaling pathway
PID NCI
Cross-References
SwissProt O95393
TrEMBL
UniProt Splice Variant
Entrez Gene 27302
UniGene Hs.158317
RefSeq NM_014482
HUGO HGNC:20869
OMIM 608748
CCDS CCDS1890
HPRD
IMGT
EMBL AC097495 AF101441 BC069080 BC101734 BC105063
GenPept AAC77462 AAH69080 AAI01735 AAI05064 AAY15075
RNA Seq Atlas 27302

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca