InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: INS

Summary

InnateDB Gene

IDBG-547491.3

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

INS

Gene Name

insulin

Synonyms

IDDM1; IDDM2; ILPR; IRDN; MODY10

Species

Homo sapiens

Ensembl Gene

ENSG00000254647

Encoded Proteins

IDBP-21414

insulin

IDBP-21418

insulin

IDBP-235748

insulin

IDBP-361792

insulin

IDBP-479810

insulin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5' region and with the IGF2 gene at the 3' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]
After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into three peptides: the B chain and A chain peptides, which are covalently linked via two disulfide bonds to form insulin, and C-peptide. Binding of insulin to the insulin receptor (INSR) stimulates glucose uptake. A multitude of mutant alleles with phenotypic effects have been identified. There is a read-through gene, INS-IGF2, which overlaps with this gene at the 5\' region and with the IGF2 gene at the 3\' region. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 11:2159779-2161341

Strand

Reverse strand

Band

p15.5

Transcripts

ENST00000381330	ENSP00000370731
ENST00000250971	ENSP00000250971
ENST00000397262	ENSP00000380432
ENST00000421783	ENSP00000408400
ENST00000512523	ENSP00000424008

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 17 experimentally validated interaction(s) in this database.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0005158	insulin receptor binding
GO:0005159	insulin-like growth factor receptor binding
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0042802	identical protein binding

Biological Process

GO:0000165	MAPK cascade
GO:0002674	negative regulation of acute inflammatory response
GO:0006006	glucose metabolic process
GO:0006112	energy reserve metabolic process
GO:0006355	regulation of transcription, DNA-templated
GO:0006521	regulation of cellular amino acid metabolic process
GO:0006953	acute-phase response
GO:0007186	G-protein coupled receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0008286	insulin receptor signaling pathway
GO:0014068	positive regulation of phosphatidylinositol 3-kinase signaling
GO:0015758	glucose transport
GO:0022898	regulation of transmembrane transporter activity
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0031018	endocrine pancreas development
GO:0031954	positive regulation of protein autophosphorylation
GO:0032148	activation of protein kinase B activity
GO:0032270	positive regulation of cellular protein metabolic process
GO:0032460	negative regulation of protein oligomerization
GO:0032880	regulation of protein localization
GO:0033861	negative regulation of NAD(P)H oxidase activity
GO:0042060	wound healing
GO:0042177	negative regulation of protein catabolic process
GO:0042593	glucose homeostasis
GO:0043410	positive regulation of MAPK cascade
GO:0044267	cellular protein metabolic process
GO:0044281	small molecule metabolic process
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045597	positive regulation of cell differentiation
GO:0045721	negative regulation of gluconeogenesis
GO:0045725	positive regulation of glycogen biosynthetic process
GO:0045740	positive regulation of DNA replication
GO:0045818	negative regulation of glycogen catabolic process
GO:0045821	positive regulation of glycolytic process
GO:0045840	positive regulation of mitosis
GO:0045861	negative regulation of proteolysis
GO:0045908	negative regulation of vasodilation
GO:0045909	positive regulation of vasodilation
GO:0045922	negative regulation of fatty acid metabolic process
GO:0046326	positive regulation of glucose import
GO:0046628	positive regulation of insulin receptor signaling pathway
GO:0046631	alpha-beta T cell activation
GO:0046889	positive regulation of lipid biosynthetic process
GO:0050708	regulation of protein secretion
GO:0050709	negative regulation of protein secretion
GO:0050715	positive regulation of cytokine secretion
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050796	regulation of insulin secretion
GO:0050995	negative regulation of lipid catabolic process
GO:0051000	positive regulation of nitric-oxide synthase activity
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051897	positive regulation of protein kinase B signaling
GO:0055089	fatty acid homeostasis
GO:0060266	negative regulation of respiratory burst involved in inflammatory response
GO:0060267	positive regulation of respiratory burst
GO:0090277	positive regulation of peptide hormone secretion
GO:0090336	positive regulation of brown fat cell differentiation
GO:1902176	negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway
GO:2000252	negative regulation of feeding behavior

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005788	endoplasmic reticulum lumen
GO:0005796	Golgi lumen
GO:0031904	endosome lumen
GO:0034774	secretory granule lumen