Version 5.4
Homo sapiens Gene: DPP3
Summary
InnateDB Gene IDBG-547507.3
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DPP3
Gene Name dipeptidyl-peptidase 3
Synonyms DPPIII
Species Homo sapiens
Ensembl Gene ENSG00000254986
Encoded Proteins
IDBP-59137
dipeptidyl-peptidase 3
IDBP-586068
dipeptidyl-peptidase 3
IDBP-583468
dipeptidyl-peptidase 3
IDBP-591649
dipeptidyl-peptidase 3
IDBP-598359
dipeptidyl-peptidase 3
IDBP-601365
dipeptidyl-peptidase 3
IDBP-604075
dipeptidyl-peptidase 3
IDBP-604077
dipeptidyl-peptidase 3
IDBP-604079
dipeptidyl-peptidase 3
IDBP-604080
dipeptidyl-peptidase 3
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is a member of the M49 family of metallopeptidases. This cytoplasmic protein binds a single zinc ion with its zinc-binding motif (HELLGH) and has post-proline dipeptidyl aminopeptidase activity, cleaving Xaa-Pro dipeptides from the N-termini of proteins. Increased activity of this protein is associated with endometrial and ovarian cancers. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:66480013-66509659
Strand Forward strand
Band q13.2
Transcripts
ENST00000360510 ENSP00000353701
ENST00000531863 ENSP00000432782
ENST00000532677 ENSP00000435284
ENST00000541961 ENSP00000440502
ENST00000531272
ENST00000532019 ENSP00000437101
ENST00000526515 ENSP00000431606
ENST00000530165 ENSP00000436941
ENST00000533725 ENSP00000434518
ENST00000544603
ENST00000531314 ENSP00000436820
ENST00000531354 ENSP00000432618
ENST00000526250
ENST00000526667
ENST00000533799
ENST00000525738
ENST00000539085
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
Experimentally validated
Total 21 [view]
Protein-Protein 20 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008237 metallopeptidase activity
GO:0008239 dipeptidyl-peptidase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000063904
View Gene Order
ENSBTAG00000022242
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.502914
RefSeq NM_001256670 NM_005700 NM_130443
HUGO
OMIM
CCDS CCDS58147 CCDS8141
HPRD 06012
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca