InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: MCM2

Summary

InnateDB Gene

IDBG-54871.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

MCM2

Gene Name

minichromosome maintenance complex component 2

Synonyms

BM28; CCNL1; cdc19; CDCL1; D3S3194; MITOTIN

Species

Homo sapiens

Ensembl Gene

ENSG00000073111

Encoded Proteins

IDBP-54873

minichromosome maintenance complex component 2

IDBP-474563

minichromosome maintenance complex component 2

IDBP-483867

minichromosome maintenance complex component 2

IDBP-484042

minichromosome maintenance complex component 2

IDBP-480022

minichromosome maintenance complex component 2

IDBP-478236

minichromosome maintenance complex component 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are involved in the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein forms a complex with MCM4, 6, and 7, and has been shown to regulate the helicase activity of the complex. This protein is phosphorylated, and thus regulated by, protein kinases CDC2 and CDC7. Multiple alternatively spliced transcript variants have been found, but the full-length nature of some variants has not been defined. [provided by RefSeq, Oct 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:127598223-127622436

Strand

Forward strand

Band

q21.3

Transcripts

ENST00000265056	ENSP00000265056
ENST00000474964	ENSP00000420007
ENST00000480910	ENSP00000419802
ENST00000472731	ENSP00000418930
ENST00000477668	ENSP00000417800
ENST00000468659
ENST00000491422	ENSP00000420528
ENST00000473785
ENST00000468414

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 126 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.

Experimentally validated
Total	126 [view]
Protein-Protein	123 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	13 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003678	DNA helicase activity
GO:0003688	DNA replication origin binding
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016851	magnesium chelatase activity
GO:0016887	ATPase activity
GO:0042393	histone binding
GO:0046872	metal ion binding

Biological Process

GO:0000082	G1/S transition of mitotic cell cycle
GO:0000278	mitotic cell cycle
GO:0006260	DNA replication
GO:0006268	DNA unwinding involved in DNA replication
GO:0006270	DNA replication initiation
GO:0006271	DNA strand elongation involved in DNA replication
GO:0006334	nucleosome assembly
GO:0007049	cell cycle
GO:0015979	photosynthesis
GO:0015995	chlorophyll biosynthetic process
GO:0032508	DNA duplex unwinding
GO:0071353	cellular response to interleukin-4

Cellular Component

GO:0000785	chromatin
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005664	nuclear origin of replication recognition complex
GO:0005737	cytoplasm
GO:0015630	microtubule cytoskeleton
GO:0042555	MCM complex