Version 5.4
Homo sapiens Gene: PRDM4
Summary
InnateDB Gene IDBG-55210.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PRDM4
Gene Name PR domain containing 4
Synonyms PFM1
Species Homo sapiens
Ensembl Gene ENSG00000110851
Encoded Proteins
IDBP-55212
PR domain containing 4
IDBP-584587
PR domain containing 4
IDBP-583305
PR domain containing 4
IDBP-590603
PR domain containing 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transcription factor of the PR-domain protein family. It contains a PR-domain and multiple zinc finger motifs. Transcription factors of the PR-domain family are known to be involved in cell differentiation and tumorigenesis. An elevated expression level of this gene has been observed in PC12 cells treated with nerve growth factor, beta polypeptide (NGF). This gene is located in a chromosomal region that is thought to contain tumor suppressor genes. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:107732866-107761272
Strand Reverse strand
Band q23.3
Transcripts
ENST00000228437 ENSP00000228437
ENST00000550376 ENSP00000446803
ENST00000549416
ENST00000550659 ENSP00000449295
ENST00000547268
ENST00000547188 ENSP00000448684
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0007165 signal transduction
GO:0008283 cell proliferation
GO:0032259 methylation
GO:0045786 negative regulation of cell cycle
GO:0048011 neurotrophin TRK receptor signaling pathway
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035529
View Gene Order
ENSBTAG00000012999
Not yet available
Pathways
NETPATH
REACTOME
REACT_13695
p75NTR negatively regulates cell cycle via SC1 pathway
REACT_11061
Signalling by NGF pathway
REACT_13776
p75 NTR receptor-mediated signalling pathway
REACT_111102
Signal Transduction pathway
KEGG
hsa04722
Neurotrophin signaling pathway pathway
INOH
PID NCI
p75ntrpathway
p75(NTR)-mediated signaling
Cross-References
SwissProt
TrEMBL H0YIF6
UniProt Splice Variant
Entrez Gene 11108
UniGene Hs.506655 Hs.705747
RefSeq NM_012406 XM_005268593 XM_006719205
HUGO HGNC:9348
OMIM 605780
CCDS CCDS9115
HPRD 10425
IMGT
EMBL AC007622
GenPept
RNA Seq Atlas 11108

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca