Version 5.4
Homo sapiens Gene: GATA2
Summary
InnateDB Gene IDBG-55213.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GATA2
Gene Name GATA binding protein 2
Synonyms DCML; IMD21; MONOMAC; NFE1B
Species Homo sapiens
Ensembl Gene ENSG00000179348
Encoded Proteins
IDBP-55215
GATA binding protein 2
IDBP-383629
GATA binding protein 2
IDBP-476078
GATA binding protein 2
IDBP-476623
GATA binding protein 2
IDBP-473762
GATA binding protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the GATA family of zinc-finger transcription factors that are named for the consensus nucleotide sequence they bind in the promoter regions of target genes. The encoded protein plays an essential role in regulating transcription of genes involved in the development and proliferation of hematopoietic and endocrine cell lineages. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:128479427-128493185
Strand Reverse strand
Band q21.3
Transcripts
ENST00000341105 ENSP00000345681
ENST00000430265 ENSP00000400259
ENST00000489987
ENST00000487848 ENSP00000417074
ENST00000492608 ENSP00000418132
ENST00000498200 ENSP00000419532
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 39 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.
Experimentally validated
Total 45 [view]
Protein-Protein 36 [view]
Protein-DNA 9 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 19 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000980 RNA polymerase II distal enhancer sequence-specific DNA binding
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0001158 enhancer sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0008270 zinc ion binding
GO:0043565 sequence-specific DNA binding
GO:0070742 C2H2 zinc finger domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001655 urogenital system development
GO:0001709 cell fate determination
GO:0001892 embryonic placenta development
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006909 phagocytosis
GO:0007596 blood coagulation
GO:0021514 ventral spinal cord interneuron differentiation
GO:0021533 cell differentiation in hindbrain
GO:0021902 commitment of neuronal cell to specific neuron type in forebrain
GO:0021954 central nervous system neuron development
GO:0021983 pituitary gland development
GO:0030154 cell differentiation
GO:0030182 neuron differentiation
GO:0035019 somatic stem cell maintenance
GO:0035065 regulation of histone acetylation
GO:0035854 eosinophil fate commitment
GO:0042472 inner ear morphogenesis
GO:0045599 negative regulation of fat cell differentiation
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045648 positive regulation of erythrocyte differentiation
GO:0045650 negative regulation of macrophage differentiation
GO:0045654 positive regulation of megakaryocyte differentiation
GO:0045746 negative regulation of Notch signaling pathway
GO:0045766 positive regulation of angiogenesis
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048469 cell maturation
GO:0048663 neuron fate commitment
GO:0048873 homeostasis of number of cells within a tissue
GO:0050766 positive regulation of phagocytosis
GO:0060216 definitive hemopoiesis
GO:0060872 semicircular canal development
GO:0070345 negative regulation of fat cell proliferation
GO:0097154 GABAergic neuron differentiation
GO:2000178 negative regulation of neural precursor cell proliferation
GO:2000977 regulation of forebrain neuron differentiation
Cellular Component
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000015053
View Gene Order
ENSBTAG00000019707
Not yet available
Pathways
NETPATH
NetPath_15
IL3 pathway
REACTOME
REACT_24970
Factors involved in megakaryocyte development and platelet production pathway
REACT_604
Hemostasis pathway
KEGG
INOH
PID NCI
hdac_classi_pathway
Signaling events mediated by HDAC Class I
ap1_pathway
AP-1 transcription factor network
hdac_classii_pathway
Signaling events mediated by HDAC Class II
hif1_tfpathway
HIF-1-alpha transcription factor network
ar_tf_pathway
Regulation of Androgen receptor activity
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.367725 Hs.709024
RefSeq NM_001145661 NM_001145662 NM_032638
HUGO
OMIM
CCDS CCDS3049 CCDS46903
HPRD 00673
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca