InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPN1

Summary

InnateDB Gene

IDBG-55262.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPN1

Gene Name

ribophorin I

Synonyms

OST1; RBPH1

Species

Homo sapiens

Ensembl Gene

ENSG00000163902

Encoded Proteins

IDBP-55264

ribophorin I

IDBP-483664

ribophorin I

IDBP-479682

ribophorin I

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:128619970-128681075

Strand

Reverse strand

Band

q21.3

Transcripts

ENST00000296255	ENSP00000296255
ENST00000497289	ENSP00000417529
ENST00000490166
ENST00000495462
ENST00000479113
ENST00000476931	ENSP00000419384
ENST00000497415
ENST00000481168

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 63 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	63 [view]
Protein-Protein	61 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004579	dolichyl-diphosphooligosaccharide-protein glycotransferase activity
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006412	translation
GO:0006464	cellular protein modification process
GO:0006486	protein glycosylation
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0018279	protein N-linked glycosylation via asparagine
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005783	endoplasmic reticulum
GO:0005789	endoplasmic reticulum membrane
GO:0005791	rough endoplasmic reticulum
GO:0008250	oligosaccharyltransferase complex
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0042470	melanosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000030062

View Gene Order

ENSBTAG00000005191

Not yet available

Pathways

NETPATH

REACTOME

REACT_22426

Asparagine N-linked glycosylation pathway

REACT_115902

SRP-dependent cotranslational protein targeting to membrane pathway

REACT_22161

Post-translational protein modification pathway

REACT_1014

Translation pathway

REACT_17015

Metabolism of proteins pathway

REACT_71

Gene Expression pathway

KEGG

hsa00510

N-Glycan biosynthesis pathway

hsa04141

Protein processing in endoplasmic reticulum pathway

INOH

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.518244 Hs.734783

RefSeq

NM_002950

HUGO

OMIM

CCDS

CCDS3051

HPRD

01598

IMGT

EMBL

GenPept

RNA Seq Atlas