Homo sapiens Gene: HAVCR2 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-55271.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | HAVCR2 | ||||||||||||||||||||||
Gene Name | hepatitis A virus cellular receptor 2 | ||||||||||||||||||||||
Synonyms | |||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000135077 | ||||||||||||||||||||||
Encoded Proteins |
hepatitis A virus cellular receptor 2
hepatitis A virus cellular receptor 2
hepatitis A virus cellular receptor 2
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
InnateDB Annotation | |||||||||||||||||||||||
Summary |
HAVCR2 is constitutively expressed on human resting monocytes/macrophages and functions as a cap to block IL12, which is a key pro-inflammatory cytokine linking innate and adaptive immune responses. HAVCR2 plays a crucial role in the negative regulation of innate immune responses through crosstalk with PDCD1 and SOCS1 to limit STAT1 phosphorylation in HCV infection.
TLR activation promotes HAVCR2 and LGALS9 association within the same macrophage to differentially regulate IL12/IL23 expressions via STAT3 phosphorylation.
Hepatitis C virus (HCV)-induced, MIR155-regulated HAVCR2 expression regulates natural killer cell function, suggesting a novel mechanism for balancing immune clearance and immune injury during chronic viral infection.
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InnateDB Annotation from Orthologs | |||||||||||||||||||||||
Summary |
[Mus musculus] Havcr2 is constitutively expressed on human resting monocytes/macrophages and functions as a cap to block Il12, which is a key pro-inflammatory cytokine linking innate and adaptive immune responses. Havcr2 plays a crucial role in the negative regulation of innate immune responses through crosstalk with Pdcd1 and Socs1 to limit Stat1 phosphorylation in HCV infection. (Demonstrated in human)
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Entrez Gene | |||||||||||||||||||||||
Summary |
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance. [provided by RefSeq, Sep 2011] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 5:157085832-157142869 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | q33.3 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
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Gene ID
Gene Order
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | E5RHN3 | ||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 84868 | ||||||||||||||||||||||
UniGene | Hs.710500 | ||||||||||||||||||||||
RefSeq | NM_032782 | ||||||||||||||||||||||
HUGO | HGNC:18437 | ||||||||||||||||||||||
OMIM | 606652 | ||||||||||||||||||||||
CCDS | CCDS4333 | ||||||||||||||||||||||
HPRD | 16227 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | AC010609 AC011377 | ||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | 84868 | ||||||||||||||||||||||