Version 5.4
Homo sapiens Gene: RAB7A
Summary
InnateDB Gene IDBG-55277.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAB7A
Gene Name RAB7A, member RAS oncogene family
Synonyms PRO2706; RAB7
Species Homo sapiens
Ensembl Gene ENSG00000075785
Encoded Proteins
IDBP-55281
RAB7A, member RAS oncogene family
IDBP-483870
RAB7A, member RAS oncogene family
IDBP-484025
RAB7A, member RAS oncogene family
IDBP-475309
RAB7A, member RAS oncogene family
IDBP-485355
RAB7A, member RAS oncogene family
IDBP-479471
RAB7A, member RAS oncogene family
IDBP-475736
RAB7A, member RAS oncogene family
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary RAB family members are small, RAS-related GTP-binding proteins that are important regulators of vesicular transport. Each RAB protein targets multiple proteins that act in exocytic / endocytic pathways. This gene encodes a RAB family member that regulates vesicle traffic in the late endosomes and also from late endosomes to lysosomes. This encoded protein is also involved in the cellular vacuolation of the VacA cytotoxin of Helicobacter pylori. Mutations at highly conserved amino acid residues in this gene have caused some forms of Charcot-Marie-Tooth (CMT) type 2 neuropathies. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:128726122-128814796
Strand Forward strand
Band q21.3
Transcripts
ENST00000265062 ENSP00000265062
ENST00000482525 ENSP00000417668
ENST00000491681
ENST00000464496 ENSP00000417978
ENST00000490093 ENSP00000418955
ENST00000493186 ENSP00000417189
ENST00000483906 ENSP00000417155
ENST00000485280 ENSP00000418283
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 54 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 54 [view]
Protein-Protein 53 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005525 GTP binding
GO:0019003 GDP binding
GO:0048365 Rac GTPase binding
Biological Process
GO:0006184 GTP catabolic process
GO:0006622 protein targeting to lysosome
GO:0006886 intracellular protein transport
GO:0006897 endocytosis
GO:0006913 nucleocytoplasmic transport
GO:0007165 signal transduction
GO:0007174 epidermal growth factor catabolic process
GO:0007264 small GTPase mediated signal transduction
GO:0008219 cell death
GO:0008333 endosome to lysosome transport
GO:0015031 protein transport
GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0045022 early endosome to late endosome transport
GO:0045453 bone resorption
GO:0090382 phagosome maturation
GO:0090383 phagosome acidification
GO:0090385 phagosome-lysosome fusion
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005770 late endosome
GO:0005794 Golgi apparatus
GO:0016020 membrane
GO:0030670 phagocytic vesicle membrane
GO:0031410 cytoplasmic vesicle
GO:0042470 melanosome
GO:0043231 intracellular membrane-bounded organelle
GO:0045335 phagocytic vesicle
GO:0070062 extracellular vesicular exosome
GO:0097208 alveolar lamellar body
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000079477
View Gene Order
ENSBTAG00000010193
Not yet available
Pathways
NETPATH
NetPath_6
KitReceptor pathway
REACTOME
REACT_121399
MHC class II antigen presentation pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04144
Endocytosis pathway
hsa05146
Amoebiasis pathway
hsa04145
Phagosome pathway
INOH
PID NCI
il8cxcr2_pathway
IL8- and CXCR2-mediated signaling events
il12_2pathway
IL12-mediated signaling events
ajdiss_2pathway
Posttranslational regulation of adherens junction stability and dissassembly
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.15738 Hs.731192
RefSeq NM_004637
HUGO
OMIM
CCDS CCDS3052
HPRD 03805
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca