InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SUMO3

Summary

InnateDB Gene

IDBG-5542.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SUMO3

Gene Name

SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)

Synonyms

SMT3A; Smt3B; SMT3H1; SUMO-3

Species

Homo sapiens

Ensembl Gene

ENSG00000184900

Encoded Proteins

IDBP-5544

SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)

IDBP-234340

SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)

IDBP-234342

SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)

IDBP-370464

SMT3 suppressor of mif two 3 homolog 3 (S. cerevisiae)

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

SUMO proteins, such as SUMO3, and ubiquitin (see MIM 191339) posttranslationally modify numerous cellular proteins and affect their metabolism and function. However, unlike ubiquitination, which targets proteins for degradation, sumoylation participates in a number of cellular processes, such as nuclear transport, transcriptional regulation, apoptosis, and protein stability (Su and Li, 2002 [PubMed 12383504]).[supplied by OMIM, Mar 2008]
This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role in a wide variety of cellular processes, including nuclear transport, DNA replication and repair, mitosis, transcriptional regulation, and signal transduction. Alternatively spliced transcript variants encoding distinct proteins have been described. [provided by RefSeq, Feb 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 21:44805617-44818779

Strand

Reverse strand

Band

q22.3

Transcripts

ENST00000332859	ENSP00000330343
ENST00000397898	ENSP00000380995
ENST00000397893	ENSP00000380990
ENST00000411651	ENSP00000409666
ENST00000479153
ENST00000466861

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 429 experimentally validated interaction(s) in this database.

Experimentally validated
Total	429 [view]
Protein-Protein	428 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019789	SUMO ligase activity

Biological Process

GO:0016925	protein sumoylation
GO:0034504	protein localization to nucleus
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:2000060	positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process

Cellular Component

GO:0000776	kinetochore
GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0016604	nuclear body
GO:0016605	PML body
GO:0070062	extracellular vesicular exosome