InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: PLAUR

Summary

InnateDB Gene

IDBG-55442.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PLAUR

Gene Name

plasminogen activator, urokinase receptor

Synonyms

CD87; U-PAR; UPAR; URKR

Species

Homo sapiens

Ensembl Gene

ENSG00000011422

Encoded Proteins

IDBP-55444

plasminogen activator, urokinase receptor

IDBP-55446

plasminogen activator, urokinase receptor

IDBP-55448

plasminogen activator, urokinase receptor

IDBP-766100

IDBP-765112

IDBP-761273

IDBP-761910

IDBP-765617

IDBP-765495

IDBP-760383

IDBP-764904

IDBP-761801

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 21998707

PLAUR is required for optimal TLR2-induced neutrophil activation. (Demonstrated in mice)

Entrez Gene

Summary

This gene encodes the receptor for urokinase plasminogen activator and, given its role in localizing and promoting plasmin formation, likely influences many normal and pathological processes related to cell-surface plasminogen activation and localized degradation of the extracellular matrix. It binds both the proprotein and mature forms of urokinase plasminogen activator and permits the activation of the receptor-bound pro-enzyme by plasmin. The protein lacks transmembrane or cytoplasmic domains and may be anchored to the plasma membrane by a glycosyl-phosphatidylinositol (GPI) moiety following cleavage of the nascent polypeptide near its carboxy-terminus. However, a soluble protein is also produced in some cell types. Alternative splicing results in multiple transcript variants encoding different isoforms. The proprotein experiences several post-translational cleavage reactions that have not yet been fully defined. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:43646095-43670547

Strand

Reverse strand

Band

q13.31

Transcripts

ENST00000339082	ENSP00000342049
ENST00000221264	ENSP00000221264
ENST00000340093	ENSP00000339328
ENST00000601876
ENST00000593939	ENSP00000472511
ENST00000593714	ENSP00000471525
ENST00000593396
ENST00000595038	ENSP00000473055
ENST00000594364
ENST00000597107	ENSP00000471307
ENST00000601723	ENSP00000471881
ENST00000602141	ENSP00000471241
ENST00000599892	ENSP00000470029
ENST00000599546	ENSP00000468863
ENST00000593447	ENSP00000470050
ENST00000598875

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 41 experimentally validated interaction(s) in this database.

Experimentally validated
Total	41 [view]
Protein-Protein	37 [view]
Protein-DNA	4 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0000981	sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0019899	enzyme binding
GO:0030377	U-plasminogen activator receptor activity

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0006501	C-terminal protein lipidation
GO:0006928	cellular component movement
GO:0006935	chemotaxis
GO:0007165	signal transduction
GO:0007596	blood coagulation
GO:0016255	attachment of GPI anchor to protein
GO:0030162	regulation of proteolysis
GO:0038195	urokinase plasminogen activator signaling pathway
GO:0042730	fibrinolysis
GO:0043687	post-translational protein modification
GO:0044267	cellular protein metabolic process
GO:0045087	innate immune response (InnateDB)

Cellular Component

GO:0005634	nucleus
GO:0005788	endoplasmic reticulum lumen
GO:0005789	endoplasmic reticulum membrane
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0016021	integral component of membrane
GO:0019898	extrinsic component of membrane
GO:0031225	anchored component of membrane
GO:0070062	extracellular vesicular exosome