Version 5.4
Homo sapiens Gene: NSF
Summary
InnateDB Gene IDBG-55627.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NSF
Gene Name N-ethylmaleimide-sensitive factor
Synonyms SKD2
Species Homo sapiens
Ensembl Gene ENSG00000073969
Encoded Proteins
IDBP-233551
N-ethylmaleimide-sensitive factor
IDBP-758091
IDBP-761675
IDBP-758142
IDBP-764279
IDBP-760521
IDBP-763238
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 17:46590669-46757464
Strand Forward strand
Band q21.31
Transcripts
ENST00000398238 ENSP00000381293
ENST00000486366
ENST00000465370 ENSP00000467779
ENST00000575068 ENSP00000458221
ENST00000571172 ENSP00000458184
ENST00000576040 ENSP00000460152
ENST00000571864 ENSP00000461448
ENST00000576346 ENSP00000459646
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 69 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 69 [view]
Protein-Protein 68 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0017075 syntaxin-1 binding
GO:0019901 protein kinase binding
GO:0019905 syntaxin binding
GO:0030165 PDZ domain binding
GO:0032403 protein complex binding
GO:0042623 ATPase activity, coupled
GO:0046872 metal ion binding
Biological Process
GO:0001921 positive regulation of receptor recycling
GO:0006200 ATP catabolic process
GO:0006813 potassium ion transport
GO:0006887 exocytosis
GO:0007268 synaptic transmission
GO:0015031 protein transport
GO:0045026 plasma membrane fusion
Cellular Component
GO:0005737 cytoplasm
GO:0005765 lysosomal membrane
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000034187
View Gene Order
ENSBTAG00000008442
Not yet available
Pathways
NETPATH
REACTOME
REACT_18422
Trafficking of GluR2-containing AMPA receptors pathway
REACT_18307
Trafficking of AMPA receptors pathway
REACT_13685
Neuronal System pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_18347
Glutamate Binding, Activation of AMPA Receptors and Synaptic Plasticity pathway
KEGG
hsa04962
Vasopressin-regulated water reabsorption pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 4905
UniGene Hs.431279 Hs.703279
RefSeq NM_006178 XM_006721929 XM_006725626
HUGO HGNC:8016
OMIM 601633
CCDS CCDS42354
HPRD 03380
IMGT
EMBL
GenPept
RNA Seq Atlas 101930324 4905

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca