InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: DAO

Summary

InnateDB Gene

IDBG-55640.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

DAO

Gene Name

D-amino-acid oxidase

Synonyms

DAAO; DAMOX; OXDA

Species

Homo sapiens

Ensembl Gene

ENSG00000110887

Encoded Proteins

IDBP-55642

D-amino-acid oxidase

IDBP-600372

D-amino-acid oxidase

IDBP-600299

D-amino-acid oxidase

IDBP-587170

D-amino-acid oxidase

IDBP-598529

D-amino-acid oxidase

IDBP-590715

D-amino-acid oxidase

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes the peroxisomal enzyme D-amino acid oxidase. The enzyme is a flavoprotein which uses flavin adenine dinucleotide (FAD) as its prosthetic group. Its substrates include a wide variety of D-amino acids, but it is inactive on the naturally occurring L-amino acids. Its biological function is not known; it may act as a detoxifying agent which removes D-amino acids that accumulate during aging. In mice, it degrades D-serine, a co-agonist of the NMDA receptor. This gene may play a role in the pathophysiology of schizophrenia. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 12:108858932-108901043

Strand

Forward strand

Band

q24.11

Transcripts

ENST00000228476	ENSP00000228476
ENST00000548052
ENST00000551281	ENSP00000446853
ENST00000547122	ENSP00000448095
ENST00000547768	ENSP00000449967
ENST00000549215	ENSP00000449248
ENST00000547166	ENSP00000447104
ENST00000546552

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003884	D-amino-acid oxidase activity
GO:0005102	receptor binding
GO:0005515	protein binding
GO:0016491	oxidoreductase activity
GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor
GO:0046983	protein dimerization activity
GO:0048037	cofactor binding
GO:0071949	FAD binding

Biological Process

GO:0006551	leucine metabolic process
GO:0006562	proline catabolic process
GO:0034641	cellular nitrogen compound metabolic process
GO:0036088	D-serine catabolic process
GO:0042416	dopamine biosynthetic process
GO:0044281	small molecule metabolic process
GO:0046487	glyoxylate metabolic process
GO:0055114	oxidation-reduction process
GO:0055130	D-alanine catabolic process
GO:0070178	D-serine metabolic process

Cellular Component

GO:0005741	mitochondrial outer membrane
GO:0005777	peroxisome
GO:0005778	peroxisomal membrane
GO:0005782	peroxisomal matrix
GO:0005829	cytosol

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000042096

View Gene Order

ENSBTAG00000018831

Not yet available

Pathways

NETPATH

REACTOME

REACT_16925

Glyoxylate metabolism pathway

REACT_13

Metabolism of amino acids and derivatives pathway

REACT_111217

Metabolism pathway

KEGG

hsa00330

Arginine and proline metabolism pathway

hsa00472

D-Arginine and D-ornithine metabolism pathway

hsa00260

Glycine, serine and threonine metabolism pathway

hsa04146

Peroxisome pathway

INOH

INOH website

Glycine Serine metabolism pathway

PID NCI

Cross-References

SwissProt

TrEMBL

UniProt Splice Variant

Entrez Gene

UniGene

Hs.113227

RefSeq

NM_001917 XM_006719268 XM_006719269

HUGO

OMIM

CCDS

CCDS9122

HPRD

15917

IMGT

EMBL

GenPept

RNA Seq Atlas