Version 5.4
Homo sapiens Gene: PTTG1IP
Summary
InnateDB Gene IDBG-5574.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PTTG1IP
Gene Name pituitary tumor-transforming 1 interacting protein
Synonyms C21orf1; C21orf3; PBF
Species Homo sapiens
Ensembl Gene ENSG00000183255
Encoded Proteins
IDBP-5576
pituitary tumor-transforming 1 interacting protein
IDBP-234370
pituitary tumor-transforming 1 interacting protein
IDBP-234372
pituitary tumor-transforming 1 interacting protein
IDBP-370506
pituitary tumor-transforming 1 interacting protein
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The encoded protein, which directly binds to pituitary tumor-transforming gene 1 protein (PTTG1), facilitates the nuclear translocation of PTTG1 and potentiates the transcriptional activation of basic fibroblast growth factor by PTTG1. The gene product localizes to both the cytoplasm and nucleus. Its NLS is required for its own nuclear localization, the nuclear localization of PTTG1, and its interaction with PTTG1. [provided by RefSeq, Jul 2008]
This gene encodes a single-pass type I integral membrane protein, which binds to pituitary tumor-transforming 1 protein (PTTG1), and facilitates translocation of PTTG1 into the nucleus. Coexpression of this protein and PTTG1 induces transcriptional activation of basic fibroblast growth factor. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 21:44849585-44873903
Strand Reverse strand
Band q22.3
Transcripts
ENST00000330938 ENSP00000328325
ENST00000397887 ENSP00000380984
ENST00000397886 ENSP00000380983
ENST00000445724 ENSP00000395374
ENST00000474737
ENST00000494690
ENST00000480234
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0004872 receptor activity
Biological Process
GO:0006606 protein import into nucleus
GO:0007275 multicellular organismal development
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000009291
View Gene Order
ENSBTAG00000021771
Not yet available
Pathways
NETPATH
NetPath_4
EGFR1 pathway
NetPath_11
TCR pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.708709
RefSeq NM_001286822 NM_004339
HUGO
OMIM
CCDS CCDS13715 CCDS68221
HPRD 04807
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca