Version 5.4
Homo sapiens Gene: ACACB
Summary
InnateDB Gene IDBG-55817.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ACACB
Gene Name acetyl-CoA carboxylase beta
Synonyms ACC2; ACCB; HACC275
Species Homo sapiens
Ensembl Gene ENSG00000076555
Encoded Proteins
IDBP-55819
acetyl-CoA carboxylase beta
IDBP-55821
acetyl-CoA carboxylase beta
IDBP-55823
acetyl-CoA carboxylase beta
IDBP-596956
acetyl-CoA carboxylase beta
IDBP-808729
acetyl-CoA carboxylase beta
IDBP-589958
acetyl-CoA carboxylase beta
IDBP-808732
acetyl-CoA carboxylase beta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]
Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. ACC-beta is thought to control fatty acid oxidation by means of the ability of malonyl-CoA to inhibit carnitine-palmitoyl-CoA transferase I, the rate-limiting step in fatty acid uptake and oxidation by mitochondria. ACC-beta may be involved in the regulation of fatty acid oxidation, rather than fatty acid biosynthesis. There is evidence for the presence of two ACC-beta isoforms. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:109116595-109268226
Strand Forward strand
Band q24.11
Transcripts
ENST00000338432 ENSP00000341044
ENST00000377854 ENSP00000367085
ENST00000377848 ENSP00000367079
ENST00000396233
ENST00000539864 ENSP00000443494
ENST00000546328
ENST00000544726 ENSP00000474680
ENST00000543080
ENST00000544651
ENST00000538526 ENSP00000443281
ENST00000542524
ENST00000534852
ENST00000537347
ENST00000536440 ENSP00000478488
ENST00000537279
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0003989 acetyl-CoA carboxylase activity
GO:0004075 biotin carboxylase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0009374 biotin binding
GO:0016874 ligase activity
GO:0046872 metal ion binding
Biological Process
GO:0006084 acetyl-CoA metabolic process
GO:0006112 energy reserve metabolic process
GO:0006633 fatty acid biosynthetic process
GO:0006766 vitamin metabolic process
GO:0006767 water-soluble vitamin metabolic process
GO:0006768 biotin metabolic process
GO:0006853 carnitine shuttle
GO:0008152 metabolic process
GO:0014070 response to organic cyclic compound
GO:0031325 positive regulation of cellular metabolic process
GO:0042493 response to drug
GO:0044255 cellular lipid metabolic process
GO:0044281 small molecule metabolic process
GO:0051289 protein homotetramerization
GO:2001295 malonyl-CoA biosynthetic process
Cellular Component
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005829 cytosol
GO:0012505 endomembrane system
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000042010
View Gene Order
ENSBTAG00000022058
Not yet available
Pathways
NETPATH
NetPath_22
Leptin pathway
REACTOME
REACT_147904
Activation of gene expression by SREBF (SREBP) pathway
REACT_147797
Regulation of cholesterol biosynthesis by SREBP (SREBF) pathway
REACT_11082
Import of palmitoyl-CoA into the mitochondrial matrix pathway
REACT_22279
Fatty acid, triacylglycerol, and ketone body metabolism pathway
REACT_2122
ChREBP activates metabolic gene expression pathway
REACT_1505
Integration of energy metabolism pathway
REACT_11153
Biotin transport and metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_169312
Defective HLCS causes multiple carboxylase deficiency pathway
REACT_169313
Defective MUT causes methylmalonic aciduria mut type pathway
REACT_169316
Defective MMAA causes methylmalonic aciduria type cblA pathway
REACT_169120
Defective TCN2 causes hereditary megaloblastic anemia pathway
REACT_11238
Metabolism of water-soluble vitamins and cofactors pathway
REACT_169280
Defective AMN causes hereditary megaloblastic anemia 1 pathway
REACT_169149
Defective MTR causes methylmalonic aciduria and homocystinuria type cblG pathway
REACT_169363
Defective LMBRD1 causes methylmalonic aciduria and homocystinuria type cblF pathway
REACT_169178
Defective CD320 causes methylmalonic aciduria pathway
REACT_169429
Defects in cobalamin (B12) metabolism pathway
REACT_169169
Defective MMACHC causes methylmalonic aciduria and homocystinuria type cblC pathway
REACT_169238
Defects in biotin (Btn) metabolism pathway
REACT_169403
Defective BTD causes biotidinase deficiency pathway
REACT_169415
Defective GIF causes intrinsic factor deficiency pathway
REACT_169385
Defects in vitamin and cofactor metabolism pathway
REACT_169132
Defective CUBN causes hereditary megaloblastic anemia 1 pathway
REACT_169256
Defective MMADHC causes methylmalonic aciduria and homocystinuria type cblD pathway
REACT_169439
Defective MTRR causes methylmalonic aciduria and homocystinuria type cblE pathway
REACT_111217
Metabolism pathway
REACT_169318
Defective MMAB causes methylmalonic aciduria type cblB pathway
REACT_116125
Disease pathway
REACT_11193
Metabolism of vitamins and cofactors pathway
KEGG
hsa00061
Fatty acid biosynthesis pathway
hsa00620
Pyruvate metabolism pathway
hsa00640
Propanoate metabolism pathway
hsa04910
Insulin signaling pathway pathway
hsa04920
Adipocytokine signaling pathway pathway
INOH
INOH website
Pyruvate metabolism pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.234898
RefSeq NM_001093 XM_005253876 XM_006719365 XM_006719367
HUGO
OMIM
CCDS CCDS31898
HPRD 07044
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca