Version 5.4
Homo sapiens Gene: TTC1
Summary
InnateDB Gene IDBG-55963.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TTC1
Gene Name tetratricopeptide repeat domain 1
Synonyms TPR1
Species Homo sapiens
Ensembl Gene ENSG00000113312
Encoded Proteins
IDBP-55965
tetratricopeptide repeat domain 1
IDBP-479380
tetratricopeptide repeat domain 1
IDBP-478690
tetratricopeptide repeat domain 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that belongs to the tetratrico peptide repeat superfamily of proteins. The encoded protein plays a role in protein-protein interactions, and binds to the Galpha subunit of G protein-coupled receptors to activate the Ras signaling pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:160009113-160065543
Strand Forward strand
Band q33.3
Transcripts
ENST00000231238 ENSP00000231238
ENST00000522793 ENSP00000429225
ENST00000522073
ENST00000520274
ENST00000518560 ENSP00000428613
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 83 experimentally validated interaction(s) in this database.
Experimentally validated
Total 83 [view]
Protein-Protein 83 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0051082 unfolded protein binding
Biological Process
GO:0006457 protein folding
Cellular Component
GO:0005778 peroxisomal membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000041278
View Gene Order
ENSBTAG00000010321
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.707461
RefSeq NM_001282500 NM_003314
HUGO
OMIM
CCDS CCDS4348
HPRD 11881
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca