Version 5.4
Homo sapiens Gene: SP2
Summary
InnateDB Gene IDBG-56378.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SP2
Gene Name Sp2 transcription factor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167182
Encoded Proteins
IDBP-56382
Sp2 transcription factor
IDBP-807445
Sp2 transcription factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the Sp subfamily of Sp/XKLF transcription factors. Sp family proteins are sequence-specific DNA-binding proteins characterized by an amino-terminal trans-activation domain and three carboxy-terminal zinc finger motifs. This protein contains the least conserved DNA-binding domain within the Sp subfamily of proteins, and its DNA sequence specificity differs from the other Sp proteins. It localizes primarily within subnuclear foci associated with the nuclear matrix, and can activate or in some cases repress expression from different promoters. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:47896150-47928957
Strand Forward strand
Band q21.32
Transcripts
ENST00000376741 ENSP00000365931
ENST00000613139 ENSP00000484898
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 15 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 15 [view]
Protein-Protein 12 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0042826 histone deacetylase binding
GO:0046872 metal ion binding
Biological Process
GO:0001701 in utero embryonic development
GO:0006351 transcription, DNA-templated
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006955 immune response
GO:0035264 multicellular organism growth
GO:0048144 fibroblast proliferation
GO:0048568 embryonic organ development
GO:0072358 cardiovascular system development
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018678
View Gene Order
ENSBTAG00000013740
Not yet available
Cross-References
SwissProt
TrEMBL Q9BRW5
UniProt Splice Variant
Entrez Gene 6668
UniGene
RefSeq NM_003110
HUGO HGNC:11207
OMIM 601801
CCDS CCDS11521
HPRD
IMGT
EMBL BC005914
GenPept AAH05914
RNA Seq Atlas 6668

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca