Homo sapiens Gene: CBLC
Summary
InnateDB Gene IDBG-56595.6
Last Modified 2013-04-25 [Report errors or provide feedback]
Gene Symbol CBLC
Gene Name Cbl proto-oncogene, E3 ubiquitin protein ligase C
Synonyms CBL-3; CBL-SL; RNF57;
Species Homo sapiens
Ensembl Gene ENSG00000142273
Encoded Proteins
Cas-Br-M (murine) ecotropic retroviral transforming sequence c
Cas-Br-M (murine) ecotropic retroviral transforming sequence c
Protein Structure
Entrez Gene
Summary This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:45281126-45303891
Strand Forward strand
Band q13.32
Transcripts
ENST00000270279 ENSP00000270279
ENST00000341505 ENSP00000340250
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 56 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 56 [view]
Protein-Protein 56 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001784 phosphotyrosine binding
GO:0004842 ubiquitin-protein ligase activity
GO:0004871 signal transducer activity
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017124 SH3 domain binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043407 negative regulation of MAP kinase activity
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Method
Confidence
Comments
SSD Ortholog
Ortholog supports species divergence
Not yet available
SSD Ortholog
Ortholog supports species divergence
Pathways
NETPATH
EGFR1 pathway
REACTOME
KEGG
Bacterial invasion of epithelial cells pathway
ErbB signaling pathway pathway
Ubiquitin mediated proteolysis pathway
Insulin signaling pathway pathway
T cell receptor signaling pathway pathway
Jak-STAT signaling pathway pathway
Chronic myeloid leukemia pathway
Endocytosis pathway
Pathways in cancer pathway
INOH
GPCR Adenosine A2A receptor signaling pathway pathway
GPCR signaling pathway
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9ULV8
TrEMBL
UniProt Splice Variant
Entrez Gene 23624
UniGene Hs.466907
RefSeq NM_001130852 NM_012116
HUGO 15961
OMIM 608453
CCDS CCDS12643 CCDS46109
HPRD 09765
IMGT
EMBL AB028645 AF117646 AF117647 BC028915
GenPept AAD34341 AAD34342 AAH28915 BAA86298
ImmGen CBLC (murine)
RNA Seq Atlas 23624