Homo sapiens Gene: CBLC

Summary
InnateDB Gene IDBG-56595.6
Last Modified 2013-04-25   [Report errors or provide feedback]
Gene Symbol CBLC
Gene Name Cbl proto-oncogene, E3 ubiquitin protein ligase C
Synonyms CBL-3; CBL-SL; RNF57
Species Homo sapiens
Ensembl Gene ENSG00000142273
Encoded Proteins
IDBP-56597 Cas-Br-M (murine) ecotropic retroviral transforming sequence c
IDBP-56599 Cas-Br-M (murine) ecotropic retroviral transforming sequence c
Entrez Gene
Summary This gene encodes a member of the Cbl family of E3 ubiquitin ligases. Cbl proteins play important roles in cell signaling through the ubiquitination and subsequent downregulation of tyrosine kinases. Expression of this gene may be restricted to epithelial cells, and alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 19: 45281126-45303891
Strand Forward strand
Band q13.32
Transcripts
ENST00000270279  ENSP00000270279
ENST00000341505  ENSP00000340250
Interactions
Number of Interactions   This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
Experimentally validated
Total 26 [view]
Protein‑Protein  26
[view]
Protein‑DNA 0
Protein‑RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
 
Gene Ontology
Accession GO Term
Molecular Function
GO:0001784 phosphotyrosine binding
GO:0004842 ubiquitin-protein ligase activity
GO:0004871 signal transducer activity
GO:0005154 epidermal growth factor receptor binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0017124 SH3 domain binding
Biological Process
GO:0007166 cell surface receptor signaling pathway
GO:0007175 negative regulation of epidermal growth factor-activated receptor activity
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042787 protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0043407 negative regulation of MAP kinase activity
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID Gene Order Method Confidence Comments
ENSMUSG00000040525 Ortholuge SSD Ortholog Ortholog supports species divergence
ENSBTAG00000009494 Not yet available Ortholuge SSD Ortholog Ortholog supports species divergence
Pathways
NETPATH
NetPath_4 EGFR1 pathway
REACTOME
KEGG
hsa05100  Bacterial invasion of epithelial cells
hsa05220  Chronic myeloid leukemia
hsa04144  Endocytosis
hsa04012  ErbB signaling pathway
hsa04910  Insulin signaling pathway
hsa04630  Jak-STAT signaling pathway
hsa05200  Pathways in cancer
hsa04660  T cell receptor signaling pathway
hsa04120  Ubiquitin mediated proteolysis
INOH
INOH website B-Raf activation signaling - GPCR Adenosine A2A receptor signaling pathway
INOH website B-Raf activation signaling - GPCR signaling (G alpha s, PKA and ERK)
INOH website Heterotrimeric GPCR signaling pathway (through Adenosine G alpha s) - GPCR Adenosine A2A receptor signaling pathway
INOH website Heterotrimeric GPCR signaling pathway (through G alpha s ACs PKA BRaf and ERKcascade) (canonical) - GPCR signaling (G alpha s, PKA and ERK)
INOH website Rap1 activation signaling (through cAMP, PKA, Cbl and C3G) - GPCR Adenosine A2A receptor signaling pathway
INOH website Rap1 activation signaling (through cAMP, PKA, Cbl and C3G) - GPCR signaling (G alpha s, PKA and ERK)
PID BIOCARTA
PID NCI
Cross-References
SwissProt Q9ULV8 
TrEMBL
UniProt Splice Variant
Entrez Gene 23624 
UniGene Hs.466907
RefSeq NM_001130852  NM_012116 
HUGO 15961 
OMIM 608453
CCDS CCDS12643  CCDS46109 
HPRD 09765
IMGT
EMBL AB028645 AF117646 AF117647 BC028915
GenPept AAD34341  AAD34342  AAH28915  BAA86298 
ImmGen CBLC (murine) 
RNA Seq Atlas 23624