Version 5.4
Homo sapiens Gene: DUSP11
Summary
InnateDB Gene IDBG-56623.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DUSP11
Gene Name dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
Synonyms PIR1
Species Homo sapiens
Ensembl Gene ENSG00000144048
Encoded Proteins
IDBP-56625
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
IDBP-380141
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
IDBP-380145
dual specificity phosphatase 11 (RNA/RNP complex 1-interacting)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which is associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene product is localized to the nucleus and binds directly to RNA and splicing factors, and thus it is suggested to participate in nuclear mRNA metabolism. [provided by RefSeq, Sep 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 2:73762184-73780157
Strand Reverse strand
Band p13.1
Transcripts
ENST00000272444 ENSP00000272444
ENST00000443070 ENSP00000413444
ENST00000452812 ENSP00000394535
ENST00000480948
ENST00000477458
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
Experimentally validated
Total 10 [view]
Protein-Protein 8 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0004651 polynucleotide 5'-phosphatase activity
GO:0004725 protein tyrosine phosphatase activity
GO:0008138 protein tyrosine/serine/threonine phosphatase activity
GO:0016791 phosphatase activity
GO:0044822 poly(A) RNA binding
GO:0098519 nucleotide phosphatase activity, acting on free nucleotides
Biological Process
GO:0006396 RNA processing
GO:0006470 protein dephosphorylation
GO:0016070 RNA metabolic process
GO:0016311 dephosphorylation
GO:0035335 peptidyl-tyrosine dephosphorylation
GO:0098507 polynucleotide 5' dephosphorylation
Cellular Component
GO:0005634 nucleus
GO:0016607 nuclear speck
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030002
View Gene Order
ENSBTAG00000033255
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.14611 Hs.608525
RefSeq NM_003584 XM_005264604
HUGO
OMIM
CCDS CCDS1928
HPRD 04368
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca