InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SERPINB9

Summary

InnateDB Gene

IDBG-56650.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SERPINB9

Gene Name

serpin peptidase inhibitor, clade B (ovalbumin), member 9

Synonyms

CAP-3; CAP3; PI-9; PI9

Species

Homo sapiens

Ensembl Gene

ENSG00000170542

Encoded Proteins

IDBP-56652

serpin peptidase inhibitor, clade B (ovalbumin), member 9

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 22167597

SERPINB9 expression in human tubular epithelial cells (TECs) is induced by triggering of the viral double-stranded RNA sensors TLR3, IFIH1 and DDX58. SERPINB9 upregulation increases the threshold for granzyme B-mediated apoptosis in TECs and protects the kidney against cytotoxic insults during viral infection.

InnateDB Annotation from Orthologs

Summary

PMID 22167597

[Mus musculus] Serpinb9 expression in tubular epithelial cells (TECs) is induced by triggering of the viral double-stranded RNA sensors Tlr3, Ifih1 and Ddx58. Serpinb9 upregulation increases the threshold for granzyme B-mediated apoptosis in TECs and protects the kidney against cytotoxic insults during viral infection. (Demonstrated in human)

Entrez Gene

Summary

This gene encodes a member of the serine protease inhibitor family which are also known as serpins. The encoded protein belongs to a subfamily of intracellular serpins. This protein inhibits the activity of the effector molecule granzyme B. Overexpression of this protein may prevent cytotoxic T-lymphocytes from eliminating certain tumor cells. A pseudogene of this gene is found on chromosome 6. [provided by RefSeq, Mar 2012]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:2887266-2903280

Strand

Reverse strand

Band

p25.2

Transcripts

ENST00000380698

ENSP00000370074

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 31 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	31 [view]
Protein-Protein	31 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0043027	cysteine-type endopeptidase inhibitor activity involved in apoptotic process

Biological Process

GO:0002448	mast cell mediated immunity
GO:0006955	immune response
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0043066	negative regulation of apoptotic process
GO:0043154	negative regulation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0045087	innate immune response (InnateDB)
GO:0071391	cellular response to estrogen stimulus

Cellular Component

GO:0005615	extracellular space
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000045827

View Gene Order

ENSBTAG00000031267

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa05146

Amoebiasis pathway

INOH

PID NCI

Cross-References

SwissProt

P50453

TrEMBL

A0A024QZT4 Q6N0A8

UniProt Splice Variant

Entrez Gene

5272

UniGene

Hs.104879 Hs.638732

RefSeq

NM_004155 XM_005249184

HUGO

HGNC:8955

OMIM

601799

CCDS

CCDS4478

HPRD

IMGT

EMBL

AB060690 AK314842 AL133351 BC002538 BT006673 BX640606 CH471087 CR407627 L40378 U71364

GenPept

AAC41940 AAC50793 AAH02538 AAP35319 BAB91078 BAG37360 CAE45712 CAG28555 CAI23290 EAW55093 EAW55094 EAW55095

RNA Seq Atlas

5272